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In gastric infiltrating lymphocytes, CCR6(+ ) CD4(+ ) CD25(high) Tregs, which express high levels of CD45RO, are positively associated with more severe inflammation in gastric mucosa during H. pylori infection. The frequency of CCR6(+) Tregs is positively correlated with the frequency of CD4(+ ) IFN-gamma(+) T cells while is inversely correlated with lower expression of IFN-gamma(+ ) CD8(+) T cells.
this study shows that CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation
CCR6 expression and its role in glioblastoma under hypoxic conditions.
The populations were identified based on the production of IFN-gamma and/or IL-17 and the coexpression of CXCR3 (X3) and CCR6 (R6).
Study demonstrated that CCR6 overexpression contributed to a poor radiotherapy effect in rectal cancer (RC) patients and radioresistance in CRC cell lines. Also the results implied that the CCR6 might enhance radioresistance through more effective DNA damage repair.
Identified a population of gut-derived TREG cells producing CCR6 and CXCR6 which are significantly reduced in inflammatory bowel disease.
CCR6 facilitates tumor angiogenesis via the AKT/NF-kappaB/VEGF pathway in colorectal cancer
expression increased on B cells of systemic lupus erythematosus patients
In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.
Bin1-N-BAR domains assemble into scaffolds of low long-range order that form flexible membrane tubule in the sarcolemma
CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity.
High expression of CCR6 is associated with cutaneous T-cell lymphoma.
CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected patients.
results provide a potential explanation for involvement of the CCL20-CCR6 system in the trafficking of IL-17-producing cells to degenerated IVD tissues
The percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
High CCR6 expression is associated with B-lymphoblastic lymphoma with inflammation.
CCR6 expression was higher in cells derived from node-positive cases and highest expression was in cells derived from metastatic cases of colon cancer.
The study suggests that a genetic interaction between DPP4 and CCR6 is involved in RA susceptibility
point mutations in CCR6 can result in either a gain or loss of receptor function
Rheumatoid arthritis-associated double nucleotide polymorphism in CCR6 regulates CCR6 via PARP-1.
gammadeltaT17 cells constitutively express chemokine receptors CCR6 and CCR2
Obesity-induced IL-6 shifts macrophage polarization towards tumor-promoting macrophages that produce the CCL-20 in the colitis-associated colorectal cancer (CAC) microenvironment. CCL-20 promotes CAC progression by recruiting CCR6-expressing B-cells and gammadelta T cells via chemotaxis.
Study identified protein and gene expression of chemokine receptor 6 in the hippocampus of Swiss mice with immunohistochemistry and RT-PCR, showed that CCR6 may be involved in normal neuronal activity in the hippocampus and play an important role in maintenance of the status epilepticus.
these data indicate that CCL20/CCR6 signaling may play an important role in regulating bone mass accrual, potentially by modulating osteoblast maturation, survival, and the recruitment of osteoblast-supporting cells.
CCR6 is upregulated rapidly within hours on the protein or mRNA level after activation in vitro.
These findings identify a crucial role for CCR6 in promoting LP-mononuclear phagocytes to associate with the intestinal epithelium in the steady state to perform multiple functions promoting gut immune homeostasis.
data suggest that gammadeltaT17 cells are completely dependent on CCR6 for homing to psoriasiform skin. Thus, CCR6 may constitute a novel target for a mechanistically distinct therapeutic approach to treating psoriasis.
Data (including data from studies using knockout mice or cells from knockout mice) suggest that HuR post-transcriptionally regulates Ccr6 expression by binding to and stabilizing Ccr6 mRNA and by promoting Ccr6 translation in helper T-cells; knock-out of HuR reduces Ccr6 expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (HuR = Hu antigen R)
CCR6 deficiency affects hepatic inflammatory cell recruitment resulting in the promotion of hepatic inflammation and fibrosis.
in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of Peyer's patches.
CCR6 might be crucial for optimal development of Th2 immune responses.
This study delineated for the first time a role for CCR6 in the development of breast cancer.
results suggest a key role for CD28 costimulation in promoting a central Treg to eTreg transition with appropriate upregulation of chemokine receptors such as CCR6 that are required for tissue homing
CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.
these data indicate that CCR6 has a supplementary role in coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for normal nTreg development.
CCR6 deficieny leads to a diminished cerebral immune response in experimental pneumococcal meningitis.
The results of this study suggest that ccr6 may play a role in cognition and learning behaviour, as well as anxiety and other behaviours.
regulates recruitment of monocytes and macrophages to the inflamed vessel promoting atherosclerosis
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
chemokine (C-C motif) receptor 6
, C-C chemokine receptor type 6
, CC chemokine receptor 6
, c-C chemokine receptor type 6-like
, G protein-coupled receptor 29
, G-protein coupled receptor 29
, LARC receptor
, chemokine (C-C) receptor 6
, chemokine receptor-like 3
, seven-transmembrane receptor, lymphocyte, 22