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Zebrafish larvae lacking beta1AR (zeige ADRB1 Proteine) expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (zeige SCP2 Proteine)), a form of synaptic plasticity that requires Cav1.2 (zeige CACNA1C Proteine) and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade.
activation of beta2AR decreased cerebral amyloid plaques through the up-regulation of alpha-secretase activity and by decreasing the phosphorylation of APP (zeige APP Proteine) at Thr668
Together, these data indicate that high-fat diet promotes phosphorylation of the beta2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin (zeige INS Proteine)-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes
beta2-AR deletion is associated to selective hepatic insulin (zeige INS Proteine) resistance and preserved skeletal muscle insulin (zeige INS Proteine) sensitivity.
The diurnal variation of the humoral immune response was dependent on beta2AR-mediated neural signals and was diminished when lymphocyte recirculation through lymph nodes was stopped.
knocking out of the beta1/2 (zeige TFAP2B Proteine) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.
The authors show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor from Cav1.2 (zeige CACNA1C Proteine) upon beta-adrenergic stimulation rendering Cav1.2 (zeige CACNA1C Proteine) refractory for several minutes from further beta-adrenergic stimulation.
The Galphas (zeige GNAS Proteine) and Galphaq (zeige GNAQ Proteine) peptides adopt different orientations in beta2-AR and V1AR (zeige AVPR1A Proteine), respectively. The beta2-AR/Galphas (zeige GNAS Proteine) peptide interface is dominated by electrostatic interactions, whereas the V1AR (zeige AVPR1A Proteine)/Galphaq (zeige GNAQ Proteine) peptide interactions are predominantly hydrophobic.
Thus the beta2AR acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function.
Data show that inhibitory (Galphai2 (zeige GNAI2 Proteine)) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 (zeige GNAI2 Proteine) over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.
These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor (zeige NR3C1 Proteine) with neonatal glucose and lipid metabolism.
ADRb2 shows lipid scrambling activity.
relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R (zeige OXTR Proteine)) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
beta2AR is linked to transcription of alpha-synuclein and risk of Parkinson's disease in a ligand-specific fashion and constitutes a potential target for therapies.
Lifetime ovulatory years were more strongly associated with ADRB2-positive ovarian tumors compared with ADRB2-negative tumors. Significant heterogeneity by ADRB2 was also observed for parity, oral contraceptive use, and age at menopause. Tumor expression of ADRB2 was not associated with ovarian cancer mortality.
ADRB2 gene polymorphism is associated with bronchodilator response in chronic obstructive pulmonary disease.
These data suggest that genetic variation of the ADRB2 may influence relative strength in healthy subjects and may become an important genetic determinant of muscular strength and functional capacity
Findings support a supramultiplicative interaction between the Gln27Glu ADRB2 variant and socioeconomic deprivation among individuals of European descent.
ADRB2 gene expressed in HIV-associated neurocognitive impairment and encephalitis chaperones OPRM1 (zeige OPRM1 Proteine), normally located intracellularly in astrocytes, to the cell surface.
X ray structure of the beta2AR bound to a polyethylene glycol-carboxylic acid derivative (Cmpd-15PA)
This study demonstrates that adverse drug events induced by ritodrine are associated with ADRB2 gene polymorphisms, as well as the infusion rate of ritodrine in pregnant women with preterm labor.
The association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2 gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2 gene makes people more susceptible to develop the disease.
a substantial proportion of the beta2AR produced is non-functional and VCP (zeige vcp Proteine) plays a key role in the maturation and trafficking of the beta2AR.
A persistent B2R (zeige BDKRB2 Proteine)-beta2AR heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR enhanced beta2AR-mediated release of tPA (zeige PLAT Proteine).
Prolactin (zeige PRL Proteine) infusion brought about the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the NO intracellular pathway
Intracoronary intermedin (zeige ADM2 Proteine) 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin (zeige CALCA Proteine) receptors and beta-adrenoreceptor-mediated nitric oxide release.
The results imply ADRB-2-mediated actions in the development of primate follicles
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
adrenergic receptor beta-2
, adrenergic, beta-2-, receptor, surface
, beta-2 adrenergic receptor
, beta-2b-adrenergic receptor
, beta-2 adrenoceptor
, beta-2 adrenoreceptor
, beta 2-AR
, adrenergic receptor beta 2
, adrenergic, beta-2, receptor, surface
, catecholamine receptor
, beta2-adrenergic receptor
, Adrenergic beta 2- receptor surface
, adrenergic receptor, beta 2
, Beta-2 adrenergic receptor
, Beta-2 adrenoceptor
, Beta-2 adrenoreceptor
, beta 2 adrenergic receptor
, beta-2-adrenergic receptor