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Zebrafish larvae lacking beta1AR expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.
the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR TG and beta2AR (zeige ADRB2 Proteine) TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins.
ghrelin (zeige GHRL Proteine) has a critical role in preventing hypoglycemia and promoting survival during severe caloric restriction, a process that requires cell-expressed beta1AR
knocking out of the beta1/2 (zeige TFAP2B Proteine) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.
Our findings that BAG3 (zeige BAG3 Proteine) is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2 (zeige CA2 Proteine)+) channel provide novel insight into the role of BAG3 (zeige BAG3 Proteine) in cardiomyopathies and increased arrhythmia risks in heart failure.
Galphai2 (zeige GNAI2 Proteine) deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.
Knockout of the C5aR1 (zeige C5AR1 Proteine) attenuated the effect of beta1-AR in the heart, suggesting an association between the beta1-AR and C5aR1 (zeige C5AR1 Proteine), although further investigation is required to determine if this is a direct or causal association
Partial gap junction uncoupling increased propensity and amplitude of Ca(2 (zeige CA2 Proteine)+) alternans, and made them more sensitive to reversal by beta-AR activation, as in isolated myocytes.
These data reveal a novel interplay between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response.
Myocardial adrenergic receptor beta 1 preferentially associates with AC5 (zeige ADCY5 Proteine).
role of beta-ARs (zeige SLURP1 Proteine) in early muscle regeneration
two barcodes are involved in sorting Wild Type ss1-AR out of early endosomes.
Data suggest that the partial agonist STD (zeige SULT2A1 Proteine)-101-D1 of beta-1 adrenergic receptor (ADRB1) is an research tool to study mechanisms of G protein-coupled receptor (zeige ADRA1A Proteine) signal transduction.
Analyzing the functional relevance of individual sites using phosphosite-deficient receptor mutants we found phosphorylation of the ADRB1 at Ser461/Ser462 in the distal part of the C-terminus to determine beta-arrestin2 (zeige ARRB2 Proteine) recruitment and receptor internalization
Studied frequency of ADRB1 Arginine389Glycine (Arg389Gly) and Cytochrome p450 2D6 (zeige CYP2D6 Proteine)*10 (Cyp2D6 (zeige CYP2D6 Proteine)*10) polymorphism in cases of heart failure-reduced ejection fraction (HFREF), and to evaluate the influence of the polymorphisms in response to beta-blocker (BB) therapy; found a statistically significant association was observed with CC genotype and Glisin-Glisin (GG) genotype.
Among individuals with previous small artery ischemic stroke, the ADRB1 Gly49 polymorphism was associated with major adverse cardiovascular events, particularly small artery ischemic stroke, a risk that may be increased among beta-blocker-treated individuals.
ADRB1 SNPs were associated with myocardial infarction susceptibility, blood pressure and plasma lipids.
the beta adrenoreceptor Gly 49 allele of the beta1 -adrenergic receptor Ser (zeige SIGLEC1 Proteine)(49) Gly polymorphisms may increase the risk of implantable cardioverter-defibrillators shock in patients with heart failure, independent of beta-blocker dosage
This study demonstrates that the polypeptide GalNAc-transferase 2 (GalNAc-T2 (zeige GALNT2 Proteine)) specifically O-glycosylates beta 1-adrenergic receptor at five residues in the extracellular N terminus, including the Ser (zeige SIGLEC1 Proteine)-49 residue at the location of the common S49G single-nucleotide polymorphism.
The minor alleles of ADRB1 and ADRB3 (zeige ADRB3 Proteine) were significantly underrepresented in kinesiology students compared with nonmajors.
The ADRB1 Gly389X genotype showed greater response to bisoprolol than the Arg389Arg genotype, suggesting the potential of individually tailoring beta-blocker therapy according to genotype in Korean heart failure patients.
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.
adrenergic, beta-1-, receptor
, beta-1 adrenergic receptor
, beta-1 adrenoceptor
, beta-1 adrenoreceptor
, adrenergic receptor, beta 1
, beta 1-adrenergic receptor beta 1-AR
, beta 1 adrenergic receptor
, beta 1 adrenergic protein
, Beta-1 adrenergic receptor
, G-protein-coupled hormone receptor
, beta 1-adrenergic receptor
, beta-1-adrenergic receptor
, tripartite motif-containing 75
, beta1-adrenergic G-protein-coupled receptor
, beta 1-AR
, cardiac beta adrenergic receptor