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SCD1 overexpression was found in Hepatocellular Carcinomas , which was associated with shorter disease-free survival.
alterations in leptin (zeige LEP Proteine) and SCD-1 in HCU patients
CD36 (zeige CD36 Proteine), also known as FA translocase (FAT), that functions as a transmembrane protein and mediates the uptake of FAs (zeige FAS Proteine), is observed to be highly expressed in breast cancer tissues. Furthermore, the anti-proliferation effect caused by the SCD1 inhibitor can not be reversed by exogenous oleic acid supplementation in CD36 (zeige CD36 Proteine) knockdown breast cancer cells
Our findings suggested that SCD1 plays a key role in the pathophysiology of leptin (zeige LEP Proteine) resistance in neuronal cells associated with obesity.
high expression of SCD1 is more frequently observed in late stage lung adenocarcinoma patients and presents poor prognosis
ULK1 (zeige ULK1 Proteine) has a role in RPS6KB1 (zeige RPS6KB1 Proteine)-NCOR1 (zeige NCOR1 Proteine) repression of NR1H/LXR (zeige NR1H3 Proteine)-mediated Scd1 transcription and augments lipotoxicity in hepatic cells
Our results suggest that relatively common genetic variants in stearoyl CoA desaturase and SREBF1 (zeige SREBF1 Proteine) attenuated the positive associations between intake of a traditional diet rich in n-3 polyunsaturated fatty acids and increases in fasting cholesterol and HbA1c levels, as well as the waist-to-hip ratio among Yup'ik participants.
Results provide evidence that SCD is a regulator of breast stemness.
these data demonstrate for the first time the involvement of SCD1 in the regulation of the Hippo pathway in lung cancer, and point to fatty acids metabolism as a key regulator of lung cancer stem cells.
High SCD1 expression is associated with resistance to cisplatin in lung cancer.
leucine deprivation induces the expression of miR (zeige MLXIP Proteine)-212-5p in a GCN2 (zeige EIF2AK4 Proteine)/ATF4 (zeige ATF4 Proteine)-dependent manner. miR (zeige MLXIP Proteine)-212-5p suppresses lipid accumulation in liver by targeting FAS (zeige FAS Proteine) and SCD1 under both normal diet and high-fat diet conditions.
The aggravated steatosis in Trif (zeige RNF138 Proteine)(-/-) mice was due to the increased hepatocyte transcription of the gene encoding stearoyl-coenzyme A (CoA) desaturase 1 (SCD1), the rate-limiting enzyme for lipogenesis.
A positive correlation among EGFR (zeige EGFR Proteine) activation, SCD1 Y55 phosphorylation and SCD1 protein expression.
BTG1 (zeige BTG1 Proteine) has a role in regulating hepatic lipid metabolism and in preventing ATF4 (zeige ATF4 Proteine) and SCD1 from inducing liver steatosis
SCD1 is a key player in the development of alcoholic fatty liver disease.
SCD1 ablation/inhibition decreased cardiac lipid content.
Our data provide evidence that SCD1 has a broad impact on WAT lipid handling by altering TAG composition in a depot-specific manner, reducing FA reesterification, and regulating markers of lipolysis and glyceroneogenesis.
SCD expressed by HSCs promoted liver tumor development in mice.
investigated the effect of genetic ablation of SCD1 in 3T3-L1 adipocytes on membrane microdomain lipid composition at the species-specific level
Splenic effector T cells (CD4 (zeige CD4 Proteine)(+)CD25 (zeige IL2RA Proteine)(-)) from age- and sex-matched wild-type (WT) and Scd1KO mice were isolated by FACS and intraperitoneally administered to Rag1KO mice, which were monitored for the development of colitis. At day 60 postcell transfer, Rag1KO mice that received Scd1KO CD4 (zeige CD4 Proteine)(+)CD25 (zeige IL2RA Proteine)(-) T cells displayed accelerated and exacerbated colitis than mice receiving WT CD4 (zeige CD4 Proteine)(+)CD25 (zeige IL2RA Proteine)(-) T cells.
Expression of SCD1 was downregulated through reduced transcription and abundance of the transcription factor sterol regulatory element-binding protein 1 (SREBP1c (zeige SREBF1 Proteine)).This effect was augmented by local chromatin tightening and DNA methylation (zeige HELLS Proteine) at and around the SREBP1c (zeige SREBF1 Proteine) binding site in the SCD1 promoter
E. coli mastitis reduced SCD1 expression in liver and udder.
Here, the association between DGAT1 (zeige DGAT1 Proteine) K232A, SCD1 A293V, and LEPR (zeige LEPR Proteine) T945M markers with milk fat composition in southern Chile was evaluated. The most frequent variants for DGAT1 (zeige DGAT1 Proteine), SCD1, and LEPR (zeige LEPR Proteine) polymorphisms were GC/GC (zeige GC Proteine), C, and C, respectively. The SCD1 CC genotype was associated with a low cholesterolemic FA content, a high ratio of linolenic acid to cholesterolemic FA, and lower conjugated-linolenic acid and PUFA content.
significant effects of the SCD gene on milk medium- and long-chain unsaturated fatty acids, especially for C14 (zeige LGALS1 Proteine):1 and C14 (zeige LGALS1 Proteine) index in dairy cattle
Studied the responsiveness of bovine SCD1 promoter to serum, insulin (zeige INS Proteine), oleic acid, and NFY transcription factor in BME-UV1 cells.
The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
Suppression of CPT1B (zeige CPT1B Proteine) and induction of SCD and CEBPB (zeige CEBPB Proteine) by supplemental arginine promotes increased adiposity in Angus steers.
This study showed that milk somatic cells can be used as a source of mRNA to study SCD1 expression in dairy cows, offering a non-invasive alternative to mammary tissue samples obtained by biopsy.
This study presents evidence that there are breed- and diet-induced variations on lipid metabolism in the muscle, which may be, at least partially, modulated by the stearoyl-CoA desaturase (SCD) gene expression levels.
These results provide detailed genetic information for the SREBP1 (zeige SREBF1 Proteine) signalling pathway and SCD that can be used to change milk fat composition by marker-assisted breeding.
whole-mount in situ hybridization and real-time quantitative RT-PCR to identify expression of the zebrafish SCD gene at five different stages of development
Results indicated that the positive effect of the T allele at the SCD gene on monounsaturated fatty acid and of the T allele at the LEPR gene on saturated fatty acid are maintained throughout the growing-finishing period, both in longissimus thoracis and subcutaneous fat.
genetic association study in Duroc gilts/barrows in Spain: Data suggest that T allele in promoter region of SCD (2228T>C) leads to up-regulation of monounsaturated fatty acid content of biceps femoris/ham which is maintained in dry-cured ham.
The study provides evidence that there exists genetic variation in the SCD gene with the potential to increase monounsaturated content in pork.
There was a positive relationship between stearoyl-CoA desaturase (SCD) protein expression in longissimus muscle and monounsaturated fatty acid content, and SCD protein expression and total muscle fatty acid content in Large White x Landrace breeds.
The relationships between a point mutation of SCD and multiple production traits in swine are reported.
The results indicate that the haplotype of the SCD gene has a strong effect on fatty acid composition and melting point of fat.
Stearoyl-CoA desaturase(SCD) has a total of 21 gene polymorphisms in the 21-kb DNA sequence, adn (zeige CFD Proteine) RT-PCR result indicates that the SCD gene is expressed ubiquitously in tissues.
SCD1 and SCD2 function in clathrin-mediated membrane trafficking essential to both cytokinesis and cell expansion.
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17.
, delta-9 desaturase
, fatty acid desaturase
, predicted protein of HQ0998
, stearoyl-CoA desaturase opposite strand
, Acyl-CoA desaturase
, acyl-CoA desaturase 1
, delta(9)-desaturase 1
, delta-9 desaturase 1
, fatty acid desaturase 1
, stearoyl-CoA desaturase 1
, stearoyl-coenzyme A desaturase
, stearoyl-CoA desaturase 5
, stearoyl-CoA desaturase
, acyl-CoA desaturase 2
, delta(9)-desaturase 2
, delta-9 desaturase 2
, fatty acid desaturase 2
, stearoyl-CoA desaturase 2
, stearoyl-Coenzyme A desaturase 2
, stearoyl-CoA desaturase (delta-9-desaturase)
, Carp Desaturase 2 (CDS2)
, acyl-CoA desaturase-like