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SPARC is closely related to the development of breast cancer and can be used as a tumor marker for breast cancer recurrence.
SPARC expression was inversely associated with the degree of malignancy and it had a negative correlation with VEGF-C (zeige VEGFC Proteine) and VEGF-D (zeige Figf Proteine) expression. Results suggest SPARC might function as a tumor suppressor inhibiting angiogenesis and lymphangiogenesis in ovarian cancer by reducing the expression of VEGF-C (zeige VEGFC Proteine) and VEGF-D (zeige Figf Proteine).
SPARC may be involved in gastric cancer metastasis by effecting on tumor microenvironment
SPARC treatment enhances the epithelial mesenchymal transition signaling pathway via activation of AKT (zeige AKT1 Proteine), and exogenous SPARC and tumor expressing SPARC might be associated with tumor progression in head and neck cancers.
The epicardial adipose tissue expresses the mRNA of osteopontin (zeige SPP1 Proteine), osteoprotegerin (zeige TNFRSF11B Proteine), and osteonectin genes that have been implicated in the calcification process; such expression is statistically associated with some components of HDL (zeige HSD11B1 Proteine) subclasses in coronary artery disease patients.
detection of SPARC mRNA and protein expression levels may facilitate early diagnosis and prognosis assessment of esophageal squamous cell carcinoma.
SPARC rs17718347 and rs2347128 single nucleotide polymorphisms are associated with progression-free survival in locally advanced and metastatic pancreatic cancer patients.
results demonstrated that loss of miR (zeige MLXIP Proteine)-211 expression and thus uncontrolled SPARC overexpression might drive progression of hepatocellular carcinoma (HCC (zeige FAM126A Proteine)), which may provide a novel therapeutic strategy for the treatment of HCC (zeige FAM126A Proteine).
Data suggest that plasma SPARC levels may be biomarker for vascular complications among Chinese type 2 diabetic patients; patients in lowest SPARC tertile have increased odds of aortic stiffness but reduced odds of peripheral arterial disease.
The profiled circulating tumour cells also expressed elevated levels of stem cell markers, and the extracellular matrix protein, SPARC. The expression of SPARC might correspond to an epithelial-mesenchymal transition in pancreatic circulating tumour cells
Sparc levels in tendons are critical for proper collagen fibril maturation.
miR (zeige MLXIP Proteine)-29 directly targeted SPARC, resulting in degradation of SPARC-encoding mRNA and reduction in the SPARC protein level.
SPARC plays a crucial role in the proliferation and differentiation of C2C12 and may be involved in the link between the ECM (zeige MMRN1 Proteine) remodeling and mitochondrial func
SPARC is regulating the interplay between myeloid-derived suppressor cells and the extracellular matrix to drive the induction of epithelial-to-mesenchymal transition in tumor cells.
The results demonstrate for the first time a functional role of the N-propeptide in regulating collagen fiber assembly and cell behavior and suggest that SPARC and the N-propeptide of collagen I have distinct activities in regulating collagen fiber assembly and fibroblast function.
SPARC plays a key role in influencing the spatial organization of the anterior segment, potentially via modulation of collagen properties, while Hevin is not likely to be involved.
An ADAMTS1 (zeige ADAMTS1 Proteine) blocking antibody suppressed the SPARC-induced collagen I secretion, indicating that SPARC promoted collagen production directly through ADAMTS1 (zeige ADAMTS1 Proteine) interaction. In conclusion, ADAMTS1 (zeige ADAMTS1 Proteine) is an important mediator of SPARC-regulated cardiac aging.
SPARC appears to be an important modulator of the actin cytoskeleton, implicating maintenance of muscular function
resistivity measurements were taken on 22 mice, 11 wild-type and 11 sparc-/- (knock out for the protein SPARC: secreted protein acidic and rich in cysteine), bearing mammary carcinomas.
SPARC isoforms, acting on Adipose stromal cells through distinct mechanisms, have an additive effect in inducing ASC (zeige STS Proteine) migration.
findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition
This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (zeige VEGFA Proteine)), fibroblast growth factor 2 (FGF2 (zeige FGF2 Proteine)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.
these data identify a contributory role for DNA methylation (zeige HELLS Proteine) in regulating sparc expression in zebrafish embryogenesis.
Results establish a role for an ECM (zeige MMRN1 Proteine) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.
Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.
Sparc is directly required for normal otolith growth
data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue
Data suggest a critical requirement for SPARC during post-gastrula development in Xenopus embryos and that SPARC, directly or indirectly, promotes cell-cell adhesion in vivo.
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.
, basement-membrane protein 40
, cysteine-rich protein
, secreted protein acidic and rich in cysteine
, Secreted acidic cystein-rich glycoprotein (osteonectin)
, secreted acidic cysteine rich glycoprotein
, secreted protein, acidic, cysteine-rich (osteonectin) S homeolog
, secreted protein, acidic, cysteine-rich (osteonectin)