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Human Beclin 1 Protein expressed in Wheat germ - ABIN1346622
Giatromanolaki, Koukourakis, Koutsopoulos, Chloropoulou, Liberis, Sivridis: High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas. in Gynecologic oncology 2011
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Human Beclin 1 Protein expressed in HEK-293 Cells - ABIN2715218
Zhu, Messer, Wang, Lin, Cham, Chang, Billiar, Lotze, Boone, Chang: Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. in The Journal of clinical investigation 2015
Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
significantly different gene expressions of BECN1 and PRKCB between the control and the Alzheimer's disease (AD) groups and of CDKN2A between the control and the preclinical AD groups, are reported.
EHMT2 (zeige EHMT2 Proteine) can directly repress Beclin-1 and the inhibition of EHMT2 (zeige EHMT2 Proteine) may be a useful therapeutic approach for cancer prevention by activating autophagy
oxidative stress activates the TRPM2 (zeige CLU Proteine)-Ca(2 (zeige CA2 Proteine)+)-CAMK2 (zeige CAMK2B Proteine) cascade to phosphorylate BECN1 resulting in autophagy inhibition
Inhibition of Beclin-1 resulted in a dramatic decline of autophagy and increase of apoptosis in drug-resistant cells, accompanied by a remarkable reduction in S phase and a raise in G2/M phase of cell cycle and reverse the effect induced by miR (zeige MLXIP Proteine)-30a-5p suppression.
AMP-activated protein kinase (AMPK (zeige PRKAA2 Proteine)) regulates autophagy by phosphorylating BECN1 at Thr388
In patients treated with immunomodulatory drugs (IMiDs) lack of or low Beclin-1 expression resulted in a significantly improved OS and PFS compared to those treated with bortezomib or nonnovel agents.
beta-asarone changed the cellular morphology, inhibited cell proliferation, and enhanced the expression of P53 (zeige TP53 Proteine), LC3 (zeige MAP1LC3A Proteine)-II/I, Beclin-1, AMPK (zeige PRKAA1 Proteine), and pAMPK while inhibiting the expression of P62 (zeige GTF2H1 Proteine), Bcl-2 (zeige BCL2 Proteine), mTOR (zeige FRAP1 Proteine), and pmTOR in glioma cells.
PINK1 (zeige PINK1 Proteine) silencing impaired BECN1 enrichment at mitochondria-associated membranes independently of PARK2 (zeige PARK2 Proteine), suggesting a novel role for PINK1 (zeige PINK1 Proteine) in regulating mitophagy.
ABHD5 (zeige ABHD5 Proteine) possesses a PNPLA2 (zeige PNPLA2 Proteine)-independent function in regulating autophagy and tumorigenesis.
BECN1-APP (zeige APP Proteine) association and BECN1-dependent APP (zeige APP Proteine) endocytosis and degradative trafficking were negatively regulated by active AKT (zeige AKT1 Proteine).
BECN1/Beclin 1 binding to viral phosphoprotein (P) induced an incomplete autophagy via activating the pathways CASP2 (zeige CASP2 Proteine)-AMPK (zeige PRKAA1 Proteine)-AKT (zeige AKT1 Proteine)-MTOR (zeige FRAP1 Proteine) and CASP2 (zeige CASP2 Proteine)-AMPK (zeige PRKAA1 Proteine)-MAPK (zeige MAPK1 Proteine) by decreasing CASP2 (zeige CASP2 Proteine).
proteostasis regulator cysteamine, which rescues the function of the most common F508del-CFTR (zeige CFTR Proteine) mutant and hence reduces lung inflammation in CF patients, can also repair the defects of CF macrophages, thus restoring both bacterial internalization and clearance through a process that involves upregulation of the pro-autophagic protein Beclin 1 and re-establishment of the autophagic pathway.
Genetically disrupting BECN1-BCL2 (zeige BCL2 Proteine) binding hyperactivates autophagy in vivo, which sequestrates amyloid oligomers and prevents Alzheimer's disease progression.
Data show that 1-month of oral treatment with beta-asarone reduces AChE, Abeta42, APP (zeige APP Proteine) and Beclin-1 levels and alleviates some behavioral impairments by inhibiting the autophagy via regulating the PI3K/Akt (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) pathway in APP (zeige APP Proteine)/PS1 (zeige PSEN1 Proteine) transgenic mice. The results further support the exploration of beta-asarone as a possible disease-modifying agent for the treatment of Alzheimer's disease.
identify FAK (zeige PTK2 Proteine) as a novel negative regulator of Beclin1-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth
The results not only demonstrate that BECN1 as a PI3K-III component is essential for cytokinesis, but also suggest that BECN1 is not associated with autophagy pathway in mouse oocytes.
this study shows that knockdown of beclin1 enhances macrophage-associated (zeige CD163 Proteine) phagocytosis and intracellular killing of Pseudomonas aeruginosa
provide the novel evidence that GADD45A (zeige GADD45A Proteine) inhibits autophagy via impairing the BECN1-PIK3C3 (zeige PIK3C3 Proteine) complex formation
in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death.
Data indicate that the expression of MAP1LC3A (zeige MAP1LC3A Proteine), B and autophagy-associated genes (ATG5 (zeige ATG5 Proteine), mTOR (zeige FRAP1 Proteine), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6