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anti-Human CAPNL1 Antikörper:
anti-Mouse (Murine) CAPNL1 Antikörper:
anti-Rat (Rattus) CAPNL1 Antikörper:
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Human Polyclonal CAPNL1 Primary Antibody für ICC, IHC (fro) - ABIN3044292
Chen, Tang, Gao, Xu, Jiang, Cao, Fu, Sun, Liu, Shi: Fibrosis, adipogenesis, and muscle atrophy in congenital muscular torticollis. in Medicine 2014
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Human Polyclonal CAPNL1 Primary Antibody für IHC (p), WB - ABIN3043467
Mo, Chen, Li, Zheng, Ke, Deng, Li, Jiang, Wu, Wang, Wang, Yang, Cao: Suppression of NHE1 by small interfering RNA inhibits HIF-1?-induced angiogenesis in vitro via modulation of calpain activity. in Microvascular research 2011
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Studies indicate that reactive oxygen and nitrogen species (RONS) and calpain play important roles in the development of airway and pulmonary vascular remodeling in COPD (zeige ARCN1 Antikörper).
Calpain-1 (zeige CAPN1 Antikörper) was significantly expressed in Triple-negative breast cancer tissues varying from low to high with a significant correlation to lymph node status but not with the other clinicopathological variables, suggesting its role as a prognostic factor
These findings suggest that calpain and AR-V7 may serve as important biomarkers in the treatment of castration-resistant prostate cancer , and targeting calpain and AR-V7 may provide a new approach in overcoming docetaxel-resistance.
Rare homozygous and compound-heterozygous nonsense, missense, frameshift, and splice-site mutations in CAPN1 were identified in all hereditary spastic paraplegia affected individuals, and sequencing in additional family members confirmed the segregation of these mutations with the disease.
the cleavage of myoferlin (zeige MYOF Antikörper), yielding a membrane-associated dual C2 domain 'mini-myoferlin (zeige MYOF Antikörper)', is reported.
mutations in CAPN1 are an additional cause of ataxia in mammals, including humans.
Calpain-1 (zeige CAPN1 Antikörper) expression is associated with poor relapse-free survival in breast cancer patients treated with trastuzumab.
Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.
HRNR (zeige HRNR Antikörper) deimination improves its cross-linking by TGases and its proteolytic processing by calpain-1 (zeige CAPN1 Antikörper).
calpains and calpastatin (zeige CAST Antikörper) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (zeige TAGLN Antikörper)-5HTT (zeige SLC6A4 Antikörper)(+) strain) PH, were investigated.
Authors provide the first evidence that calpain-1 (zeige CAPN1 Antikörper) regulates platelet hyperactivity in sickle mice.
A total of 55 genes were differentially expressed in micro-calpain knockout mice.
calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2 (zeige MMP2 Antikörper)/TGF-beta1 (zeige TGFB1 Antikörper) pathway.
indicate that calpain-1 (zeige CAPN1 Antikörper) and calpain-2 (zeige CAPN2 Antikörper) play opposite roles in high increased intraocular pressure-induced ischemic injury
Results strengthen the roles of both calpain-1 (zeige CAPN1 Antikörper) and PHLPP1 (zeige PHLPP1 Antikörper) in synaptic plasticity and learning and memory, and illustrate the complexities of the interactions between multiple pathways participating in synaptic plasticity.
Genetic ablation of calpain-1 (zeige CAPN1 Antikörper) ameliorates chronic pain behavior in sickle cell mice.
Our results indicate that calpain mediates cytokine-induced collagen-I synthesis and proliferation of ASMCs via the mTORC2 (zeige CRTC2 Antikörper)/Akt (zeige AKT1 Antikörper) signalling pathway, thereby regulating airway smooth muscle remodelling in asthma.
Results indicate that calpain-1 (zeige CAPN1 Antikörper) and calpain-2 (zeige CAPN2 Antikörper) are differentially activated in hippocampus following seizure activity, with calpain-1 (zeige CAPN1 Antikörper) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 (zeige CAPN2 Antikörper) is widely activated in pyramidal neurons of CA1 (zeige CA1 Antikörper) and CA3 (zeige CA3 Antikörper), and triggers neurodegenerative cascades.
Here we show the combined loss of glial glutamate (zeige GRIN1 Antikörper) transporters GLT1 (zeige SLC1A2 Antikörper) and GLAST (zeige SLC1A3 Antikörper) in spinal cord caused motor neuronal death and hindlimb paralysis.
CAPN1 HM535412:g.157T > C showed effect on meat redness.
The decreased expression of calpain 1A mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
Right ventricular (RV) dysfunction from acute RV pressure overload is, in part, due to activation of calpain, and calpain inhibition would therefore attenuate RV dysfunction.
catalytic site amino acid residues 105-133 contained a disulfide bond between Cys (zeige DNAJC5 Antikörper)(108) and Cys (zeige DNAJC5 Antikörper)(115)
Association of polymorphisms with breed characteristics indicated that the mutations in CAPN1 detected by P4, P6 primers and that resulting in the change of Hinf 1 recognition site may be related to lean meat percentage.
The activities of Calpain and PLA2 (zeige YWHAZ Antikörper) on the muscle tissue of the bladders were analyzed.
Most heifer reproductive traits were not significantly affected by CAST and CAPN1 markers that are widely used to improve beef tenderness by selection and breeders should not be concerned with how these markers affect reproduction and other heifer traits with the possible exception of CAPN1 effects on calving date.
study is the first report on genetic variant g.-1256 A>C in the promoter region of CAPN1 gene association with the semen quality of Chinese Holstein bulls by influencing its expression
This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef.
Suppression of CANP1 resulted in the activation of caspase (zeige CASP3 Antikörper) and heat-shock-protein systems which might in turn regulate apoptosis through the caspase (zeige CASP3 Antikörper)-dependent cell death pathway. [CANP1]
bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures
This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (zeige GHR Antikörper) as a selection marker for beef quality.
It was found that the marker c.3379G > A in the CAPN1 gene influences the Ca content in the meat of this Nelore population, with the rare genotype associated with less Ca content.
m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.
Association of polymorphisms in calpain 1 (zeige CAPN1 Antikörper), (mu/I) large subunit, calpastatin (zeige CAST Antikörper), and cathepsin D (zeige CTSD Antikörper) genes with meat quality traits in double-muscled Piemontese cattle.
Relationships of the calpain system with meat tenderness and carcass traits were examined for 94 purebred Angus bulls.
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain, large polypeptide L1
, calpain-1 catalytic subunit
, calpain-1 large subunit
, cell proliferation-inducing gene 30 protein
, cell proliferation-inducing protein 30
, calpain 1, large subunit
, micromolar calcium-activated neutral protease 1
, micromolar calcium activated neutral protease 1
, mu-calpain large subunit