PPM1A Antikörper (AA 202-382)
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- Target Alle PPM1A Antikörper anzeigen
- PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
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Bindungsspezifität
- AA 202-382
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Reaktivität
- Human, Affe
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser PPM1A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. coli. ,
- Klon
- 7F12
- Isotyp
- IgG1
- Top Product
- Discover our top product PPM1A Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).
: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." in: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).
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Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).
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- Target
- PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
- Andere Bezeichnung
- PPM1A (PPM1A Produkte)
- Synonyme
- PP2C-ALPHA antikoerper, PP2CA antikoerper, PP2Calpha antikoerper, pp2ca1 antikoerper, ppp1r13b antikoerper, si:ch211-253p18.1 antikoerper, wu:fd42g12 antikoerper, zgc:153820 antikoerper, 2310003C21Rik antikoerper, 2900017D14Rik antikoerper, AI427932 antikoerper, AU017636 antikoerper, MMPa-2 antikoerper, MPPa-1 antikoerper, Pp2c1 antikoerper, pp2c-alpha antikoerper, pp2ca antikoerper, pp2calpha antikoerper, pp2ca2 antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1A antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Ab antikoerper, protein phosphatase 1A, magnesium dependent, alpha isoform antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1A antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Aa antikoerper, PPM1A antikoerper, ppm1ab antikoerper, Ppm1a antikoerper, ppm1a.L antikoerper, ppm1aa antikoerper
- Hintergrund
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Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Aliases: PP2CA, PP2Calpha, PP2C-ALPHA
- Molekulargewicht
- 42.4 kDa
- Gen-ID
- 5494
- HGNC
- 5494
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