AP2M1 Antikörper (AA 110-230)
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- Target Alle AP2M1 Antikörper anzeigen
- AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))
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Bindungsspezifität
- AA 110-230
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser AP2M1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF)
- Kreuzreaktivität
- Ratte (Rattus), Human
- Produktmerkmale
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. - Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Mouse AP50/mu2 aa. 110-230
- Klon
- 31-AP50
- Isotyp
- IgG1
- Top Product
- Discover our top product AP2M1 Primärantikörper
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- Kommentare
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Related Products: ABIN968545, ABIN967389, ABIN968533
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store undiluted at -20°C.
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Nucleocytoplasmic shuttling of endocytic proteins." in: The Journal of cell biology, Vol. 153, Issue 7, pp. 1511-7, (2001) (PubMed).
: "Interaction of tyrosine-based sorting signals with clathrin-associated proteins." in: Science (New York, N.Y.), Vol. 269, Issue 5232, pp. 1872-5, (1995) (PubMed).
: "
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Nucleocytoplasmic shuttling of endocytic proteins." in: The Journal of cell biology, Vol. 153, Issue 7, pp. 1511-7, (2001) (PubMed).
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- Target
- AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))
- Andere Bezeichnung
- AP50 (AP2M1 Produkte)
- Synonyme
- AP50 antikoerper, CLAPM1 antikoerper, mu2 antikoerper, Ap50 antikoerper, Clapm1 antikoerper, cb34 antikoerper, Ap2m1 antikoerper, dpy-23 antikoerper, sb:cb34 antikoerper, zgc:55711 antikoerper, zgc:85653 antikoerper, wu:fa97a10 antikoerper, ap2m1-a antikoerper, ap2m1 antikoerper, zgc:56643 antikoerper, AP2M1 antikoerper, adaptor related protein complex 2 mu 1 subunit antikoerper, adaptor-related protein complex 2, mu 1 subunit antikoerper, adaptor-related protein complex 2, mu 1 subunit, a antikoerper, adaptor related protein complex 2 mu 1 subunit L homeolog antikoerper, adaptor-related protein complex 2, mu 1 subunit, b antikoerper, AP-2 complex subunit mu-1 antikoerper, clathrin coat assembly protein AP50 antikoerper, clathrin coat assembly protein ap50 antikoerper, AP2M1 antikoerper, Ap2m1 antikoerper, ap2m1a antikoerper, ap2m1.L antikoerper, ap2m1b antikoerper, ap2m1 antikoerper, cgd8_950 antikoerper, PY06523 antikoerper, PVX_118455 antikoerper, PVX_123590 antikoerper, CpipJ_CPIJ003697 antikoerper
- Hintergrund
- Sorting of integral membrane proteins is mediated vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (gamma, alpha, delta, epsilon, and beta1, beta2, beta3, beta4 respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, µ4 respectively) and one small chain ( sigma1, sigma2, sigma3, sigma4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2, µ2 (AP50) interacts with integral membrane proteins via binding to tyrosine-based signals with the canonical motif YXXPhi. In addition, AP50/µ2 is required for both the assembly and the proton transport activity of vacuolar (H+)-ATPases in clathrin coated vesicles. Thus, AP50/µ2 may be involved in targeting integral membrane proteins that are sorted based on tyrosine-based signals and involved in assembly of functional ion channels associated with clathrin coated vesicles.
- Molekulargewicht
- 50 kDa
- Pathways
- EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom
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