RABEP1 Antikörper (AA 247-417)

Produktnummer ABIN968104

Produktdetails anti-RABEP1 Antikörper

Target: RABEP1 (Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1))

Bindungsspezifität: AA 247-417

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RABEP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Kreuzreaktivität: Maus, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Rabaptin-5 aa. 247-417.

Klon: 20-Rabaptin

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968585, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-RABEP1 Antikörper (ABIN968104)

Shiba, Takatsu, Shin, Nakayama: "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain." in: Journal of biochemistry, Vol. 131, Issue 3, pp. 327-36, (2002) (PubMed).

Zhu, Doray, Poussu, Lehto, Kornfeld: "Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor." in: Science (New York, N.Y.), Vol. 292, Issue 5522, pp. 1716-8, (2001) (PubMed).

Stenmark, Vitale, Ullrich, Zerial: "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion." in: Cell, Vol. 83, Issue 3, pp. 423-32, (1996) (PubMed).

Details zu RABEP1

Target: RABEP1 (Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1))

Andere Bezeichnung: Rabaptin-5 (RABEP1 Produkte)

Synonyme: RAB5EP antikoerper, RABPT5 antikoerper, AA409789 antikoerper, AI481320 antikoerper, AV213537 antikoerper, AW240603 antikoerper, Rab5ep antikoerper, rabaptin-5 antikoerper, rabaptin, RAB GTPase binding effector protein 1 antikoerper, RABEP1 antikoerper, Rabep1 antikoerper

Hintergrund: Rabs are small GTP-binding proteins that are localized to specific intracellular vesicles and organelles. They are important for the regulation of vesicular traffic. It is thought that Rabs cycle between GTP- and GDP-bound forms and this cycle is related to their function. Rabaptin-5 is protein that interacts with GTP-Rab5. Although Rabaptin-5 is localized in the cytosol, it is also recruited to the endosomal fraction in a Rab5 and GTP-dependent manner. The removal of Rabaptin-5 from the cytosol substantially impairs GTP and Rab5-dependent endosomal fusion. This indicates that Rabaptin-5 may be an important partner of Rab5 during endocytosis. Rabaptin-5 contains 862 amino acids and both ends of the protein contain coiled-coil domains typically found in vesicular transport proteins. This antibody is routinely tested by western blot analysis.

Molekulargewicht: 117 kDa