Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human SLC4A11 (Sodium bicarbonate transporter-like protein 11)
Jiao, Sultana, Garg, Ramamurthy, Vemuganti, Gangopadhyay, Hejtmancik, Kannabiran: "Autosomal recessive corneal endothelial dystrophy (CHED2) is associated with mutations in SLC4A11." in: Journal of medical genetics, Vol. 44, Issue 1, pp. 64-8, (2007) (PubMed).
Desir, Moya, Reish, Van Regemorter, Deconinck, David, Meire, Abramowicz: "Borate transporter SLC4A11 mutations cause both Harboyan syndrome and non-syndromic corneal endothelial dystrophy." in: Journal of medical genetics, Vol. 44, Issue 5, pp. 322-6, (2007) (PubMed).
Park, Li, Shcheynikov, Zeng, Muallem: "NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation." in: Molecular cell, Vol. 16, Issue 3, pp. 331-41, (2004) (PubMed).
Parker, Ourmozdi, Tanner: "Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney." in: Biochemical and biophysical research communications, Vol. 282, Issue 5, pp. 1103-9, (2001) (PubMed).
Target
SLC4A11
(Solute Carrier Family 4, Sodium Borate Transporter, Member 11 (SLC4A11))
NaBC1 antikoerper, si:dkey-12j14.4 antikoerper, AI503023 antikoerper, BTR1 antikoerper, CDPD1 antikoerper, CHED2 antikoerper, NABC1 antikoerper, dJ794I6.2 antikoerper, solute carrier family 4 member 11 antikoerper, solute carrier family 4 member 11 L homeolog antikoerper, solute carrier family 4, sodium borate transporter, member 11 antikoerper, solute carrier family 4, sodium bicarbonate transporter-like, member 11 antikoerper, Slc4a11 antikoerper, SLC4A11 antikoerper, slc4a11.L antikoerper, slc4a11 antikoerper
Hintergrund
SLC4A11 (Sodium bicarbonate transporter-like protein 11) involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. SLC4A11 (Sodium bicarbonate transporter-like protein 11) is a multi-pass membrane protein. SLC4A11 is highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD), also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM:217700], also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive.