NOS1 Antikörper (C-Term)

Produktnummer ABIN966677

Produktdetails anti-NOS1 Antikörper

Target: NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Nitric oxide synthase, brain (NOS1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human NOS1 , identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

Details zu NOS1

Target: NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))

Andere Bezeichnung: Nitric oxide synthase, brain (NOS1 Produkte)

Synonyme: NOS1 antikoerper, IHPS1 antikoerper, N-NOS antikoerper, NC-NOS antikoerper, NOS antikoerper, bNOS antikoerper, nNOS antikoerper, 2310005C01Rik antikoerper, NO antikoerper, NOS-I antikoerper, Nos-1 antikoerper, nos antikoerper, ihps1 antikoerper, nnos antikoerper, nos1 antikoerper, nos1-A antikoerper, nanos C2HC-type zinc finger 1 antikoerper, nitric oxide synthase 1 antikoerper, nitric oxide synthase 1, neuronal antikoerper, nitric oxide synthase 1 (neuronal) antikoerper, nitric oxide synthase 1 L homeolog antikoerper, NANOS1 antikoerper, NOS1 antikoerper, Nos1 antikoerper, nos1 antikoerper, nos1.L antikoerper

Hintergrund: Nitric Oxide Synthase 1 (NOS1,neuronal NOS,nNOS1) is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. It may be involved in neuronal cell death and damage in neurological illness. nNOS1 localized to the 12q24. 2 region of human chromosome 12. It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098 amino acids. nNOS cDNA clones were shown to contain different 5' terminal exons spliced to a common exon 2. Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300 bp of each other but separated from exon 2 by an intron that is at least 20 kb in length. The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle. The novel gaseous neuromediator nitric oxide is thought to play an important role in development and plasticity. Despite this, gene-knockout mice lacking neuronal (Type I) nitric oxide synthase exhibit relatively normal brain development and behavior.

Pathways: Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction