ERK2 Antikörper

Produktnummer ABIN966090

Produktdetails anti-ERK2 Antikörper

Target: ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser ERK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: Ni-NTA purified full length recombinant ERK2 expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Antibodies are purified by protein A affinity chromatography

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Referenzen für anti-ERK2 Antikörper (ABIN966090)

Whitehurst, Robinson, Moore, Cobb: "The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12840-7, (2004) (PubMed).

Begum, Asghar, N, Khan, Khan: "High dose rate intraluminal brachytherapy in combination with external beam radiotherapy for palliative treatment of cancer rectum." in: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, Vol. 13, Issue 11, pp. 633-6, (2003) (PubMed).

Details zu ERK2

Target: ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))

Andere Bezeichnung: ERK2 (MAPK1 Produkte)

Hintergrund: ERK2 (also designated extracellular-signal-related kinase 2 or mitogen-activated protein kinase 1), with 360-amino acid protein (about 40kDa), belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of ERK2 requires its phosphorylation by upstream kinases. ERK2 is located in the cytoplasm of resting cells and translocates into the nucleus upon extracellular stimuli by active transport of a dimer. ERK2 is essential for placental development and ERK2 in the trophoblast compartment may be indispensable for the vascularization of the labyrinth.

Gen-ID: 5594

Pathways: MAPK Signalweg, RTK Signalweg, Apoptose, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagie, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, S100 Proteine