p300 Antikörper

Produktnummer ABIN966068

Produktdetails anti-p300 Antikörper

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser p300 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of EP300 expressed in E. Coli.

Klon: 7D8A6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-p300 Antikörper (ABIN966068)

Geiger, Sharma, Kim, Nyborg: "The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB." in: Molecular and cellular biology, Vol. 28, Issue 4, pp. 1383-92, (2008) (PubMed).

Stauffer, Chang, Huang, Dunn, Thayer: "p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint." in: The Journal of biological chemistry, Vol. 282, Issue 13, pp. 9678-87, (2007) (PubMed).

Details zu p300

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Andere Bezeichnung: EP300 (EP300 Produkte)

Synonyme: KAT3B antikoerper, RSTS2 antikoerper, p300 antikoerper, A430090G16 antikoerper, A730011L11 antikoerper, p300 HAT antikoerper, E1A binding protein p300 antikoerper, histone acetyltransferase p300 antikoerper, EP300 antikoerper, LOC446056 antikoerper, ep300 antikoerper, Ep300 antikoerper

Hintergrund: EP300: E1A binding protein p300. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional coactivator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Synonyms: p300, KAT3B

Gen-ID: 2033

Pathways: p53 Signalweg, Notch Signalweg, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size