Hwang, Lee, Kim, Li, Jin, Rhee, Kim, Lim: "Calcyclin, a Ca2+ ion-binding protein, contributes to the anabolic effects of simvastatin on bone." in: The Journal of biological chemistry, Vol. 279, Issue 20, pp. 21239-47, (2004) (PubMed).
Calcyclin encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.