eIF4EBP1 Antikörper
(2 Referenzen)Kurzübersicht für eIF4EBP1 Antikörper (ABIN965483)
Target
Alle eIF4EBP1 (EIF4EBP1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Spezifität
- Ni-NTA purified truncated recombinant 4EBP1 expressed in E. Coli strain BL21 (DE3).
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Aufreinigung
- Antibodies are purified by protein A affinity chromatography
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Isotyp
- IgG1
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anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pThr37), (pThr46) antibody
EIF4EBP1 Reaktivität: Human, Maus WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (C-Term) antibodyEIF4EBP1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pSer65) antibodyEIF4EBP1 Reaktivität: Human IHC, ELISA, ICC, FACS Wirt: Maus Monoclonal 1E2E7 unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pThr46) antibodyKD Validated EIF4EBP1 Reaktivität: Human WB, FACS Wirt: Kaninchen Monoclonal 24GB4405 unconjugated Recombinant Antibody
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 1-118) antibodyEIF4EBP1 Reaktivität: Human WB, ELISA, IF, PLA Wirt: Maus Monoclonal 4F3-H2 unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pThr36) antibodyEIF4EBP1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pSer65) antibodyEIF4EBP1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) antibodyKD Validated EIF4EBP1 Reaktivität: Human WB, FACS Wirt: Kaninchen Monoclonal 24GB4410 unconjugated Recombinant Antibody
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 2-118) antibodyEIF4EBP1 Reaktivität: Human WB, IHC, ICC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pThr45) antibodyEIF4EBP1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
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Western Blot: 1: 500- 1: 1,000.
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Lagerung
- -20 °C
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: "Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes." in: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10240-7, (1997) (PubMed).
: "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function." in: Nature, Vol. 371, Issue 6500, pp. 762-7, (1994) (PubMed).
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- eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
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Andere Bezeichnung
- 4E-BP1
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Hintergrund
- 4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
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Gen-ID
- 1978
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Pathways
- MAPK Signalweg, PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Regulation of Cell Size, BCR Signaling
Target
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