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OspC Antikörper

Reaktivität: Borrelia burgdorferi ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN964717
  • Target
    OspC
    Reaktivität
    Borrelia burgdorferi
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Applikation
    ELISA, Western Blotting (WB)
    Spezifität
    This product was Protein-A purified and cross-adsorbed against MBP from monospecific antiserum by chromatography. This antibody is specific for Borrelia burgdorferi OspC protein. A BLAST analysis was used to suggest cross-reactivity with p39 from B. burgdorferi, afzelii, and valaisiana sources based on 100% homology with the immunizing sequence. Partial reactivity is expected against B. japonica and americana sources based on 94% homology. Cross-reactivity with OspC from other sources has not been determined.
    Produktmerkmale
    Outer Surface Protein C, or OspC, is a 20.7 kDa immunogenic protein on the outer surface of the spirochete Borrelia burgdorferi. Its function is not known, but it is located with lipid-anchoring sites on the outer cell membrane.
    Aufreinigung
    purified
    Sterilität
    Sterile filtered
    Immunogen
    MBP-fusion protein corresponding to Borrelia burgdorferi OspC protein.
    Immunogen Type: RecombinantProtein
    Isotyp
    IgG
  • Applikationshinweise
    This protein-A purified antibody has been tested for use in Western blotting and in ELISA. Specific conditions for reactivity should be optimized by the user. Expect a band approximately 20.7 kDa in size corresponding to Borrelia burgdorferi OspC protein by Western blotting in the appropriate cell lysate or extract.
    Kommentare

    Gene Name: ospC, BB_B19

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 100 µL
    Konzentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Haltbarkeit
    12 months
  • Karvonen, Tammisto, Nykky, Gilbert: "Borrelia burgdorferi Outer Membrane Vesicles Contain Antigenic Proteins, but Do Not Induce Cell Death in Human Cells." in: Microorganisms, Vol. 10, Issue 2, (2022) (PubMed).

    Joung, Ballard, Ma, Tseng, Teshome, Burakowski, Garner, Di Carlo, Ozcan: "Paper-based multiplexed vertical flow assay for point-of-care testing." in: Lab on a chip, Vol. 19, Issue 6, pp. 1027-1034, (2019) (PubMed).

    Caine, Lin, Kessler, Sato, Leong, Coburn: "Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival." in: Cellular microbiology, Vol. 19, Issue 12, (2018) (PubMed).

    Caine, Coburn: "A short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream survival conferred by adhesion proteins." in: Infection and immunity, Vol. 83, Issue 8, pp. 3184-94, (2015) (PubMed).

  • Target
    OspC
    Hintergrund
    Outer Surface Protein C, or OspC, is a 20.7 kDa immunogenic protein on the outer surface of the spirochete Borrelia burgdorferi. Its function is not known, but it is located with lipid-anchoring sites on the outer cell membrane.
    Synonyms: OspC, Borrelia burgdorferi OspC, PC, Outer Surface Protein C
    Gen-ID
    1194415
    NCBI Accession
    NP_047005
    UniProt
    Q07337
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