SLC6A3 Antikörper (Internal Region)

Produktnummer ABIN954827

Produktdetails anti-SLC6A3 Antikörper

Target: SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SLC6A3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-QLTSSTLTNP RQSP

Spezifität: Recognizes SLC6A3 / DAT

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region (near N Terminus) of the protein sequence according to NP_001035.1. Genename: SLC6A3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-SLC6A3 Antikörper (ABIN954827)

Wiers, Lohoff, Lee, Muench, Freeman, Zehra, Marenco, Lipska, Auluck, Feng, Sun, Goldman, Swanson, Wang, Volkow: "Methylation of the dopamine transporter gene in blood is associated with striatal dopamine transporter availability in ADHD: A preliminary study." in: The European journal of neuroscience, Vol. 48, Issue 3, pp. 1884-1895, (2018) (PubMed).

Details zu SLC6A3

Target: SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3))

Andere Bezeichnung: SLC6A3 / DAT (SLC6A3 Produkte)

Synonyme: DAT antikoerper, SLC6A3 antikoerper, Dat1 antikoerper, DAT1 antikoerper, PKDYS antikoerper, solute carrier family 6 member 3 antikoerper, solute carrier family 6 (neurotransmitter transporter), member 3 antikoerper, Sodium-dependent dopamine transporter antikoerper, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 antikoerper, SLC6A3 antikoerper, slc6a3 antikoerper, dat-1 antikoerper, Slc6a3 antikoerper

Hintergrund: Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. It is a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm.Synonyms: DA transporter, DAT1, Sodium-dependent dopamine transporter, Solute carrier family 6 member 3

Gen-ID: 6531

NCBI Accession: NP_001035

Pathways: Dopaminergic Neurogenesis