DCC Antikörper (Middle Region)

Produktnummer ABIN953653

Produktdetails anti-DCC Antikörper

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Bindungsspezifität: AA 642-670, Middle Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human and Mouse DCC (Center).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 642-670 amino acids from the Central region of Human DCC. Genename: DCC

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DCC

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Andere Bezeichnung: Netrin Receptor DCC (DCC Produkte)

Synonyme: CRC18 antikoerper, CRCR1 antikoerper, IGDCC1 antikoerper, MRMV1 antikoerper, DCC antikoerper, zdcc antikoerper, C030036D22Rik antikoerper, Igdcc1 antikoerper, xdcc antikoerper, XDCCa antikoerper, dcca-A antikoerper, Dcc antikoerper, DCC netrin 1 receptor antikoerper, deleted in colorectal carcinoma antikoerper, netrin receptor DCC antikoerper, DCC antikoerper, dcc antikoerper, Dcc antikoerper, LOC100712666 antikoerper

Hintergrund: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.Synonyms: CRC18, CRCR1, Colorectal cancer suppressor, IGDCC1, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC

Molekulargewicht: 158457 Da

Gen-ID: 1630

NCBI Accession: NP_005206

Pathways: Regulation of Cell Size