FGD4 Antikörper (N-Term)

Produktnummer ABIN952304

Produktdetails anti-FGD4 Antikörper

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Bindungsspezifität: AA 156-186, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to FGD4.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 156-186 amino acids from the N-terminal region of human FGD4

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FGD4

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Andere Bezeichnung: FGD4 (FGD4 Produkte)

Synonyme: CMT4H antikoerper, FRABP antikoerper, ZFYVE6 antikoerper, 9030023J02Rik antikoerper, 9330209B17Rik antikoerper, Frabp antikoerper, FYVE, RhoGEF and PH domain containing 4 antikoerper, FGD4 antikoerper, Fgd4 antikoerper

Hintergrund: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq].Synonyms: Actin filament-binding protein frabin, FGD1-related F-actin-binding protein, FRABP, FYVE, Frabin, RhoGEF and PH domain-containing protein 4, ZFYVE6, Zinc finger FYVE domain-containing protein 6

Molekulargewicht: 86626 Da

Gen-ID: 121512

NCBI Accession: NP_640334

Pathways: Neurotrophin Signalübertragung