TRPV4 Antikörper (AA 301-400) (HRP)
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- Target Alle TRPV4 Antikörper anzeigen
- TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
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Bindungsspezifität
- AA 301-400
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Reaktivität
- Human, Rind (Kuh)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TRPV4 Antikörper ist konjugiert mit HRP
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Rind (Kuh), Human
- Homologie
- Mouse,Rat,Dog,Cow,Pig,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human TRPV4
- Isotyp
- IgG
- Top Product
- Discover our top product TRPV4 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
- Andere Bezeichnung
- TRP12 (TRPV4 Produkte)
- Synonyme
- wu:fp52e02 antikoerper, CMT2C antikoerper, HMSN2C antikoerper, OTRPC4 antikoerper, SMAL antikoerper, SPSMA antikoerper, SSQTL1 antikoerper, TRP12 antikoerper, VRL2 antikoerper, VROAC antikoerper, 0610033B08Rik antikoerper, Trp12 antikoerper, VR-OAC antikoerper, VRL-2 antikoerper, Otrpc4 antikoerper, Vroac antikoerper, transient receptor potential cation channel, subfamily V, member 4 antikoerper, transient receptor potential cation channel subfamily V member 4 antikoerper, trpv4 antikoerper, TRPV4 antikoerper, Trpv4 antikoerper
- Hintergrund
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Synonyms: SMAL, VRL2, BCYM3, CMT2C, SPSMA, TRP12, VROAC, HMSN2C, OTRPC4, SSQTL1, Transient receptor potential cation channel subfamily V member 4, TrpV4, Osm-9-like TRP channel 4, Transient receptor potential protein 12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC
Background: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH , citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
- Gen-ID
- 59341
- UniProt
- Q9HBA0
- Pathways
- Hormone Transport, Cell-Cell Junction Organization
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