Integrin beta 3 Antikörper (AA 27-120) (Alexa Fluor 350)
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- Target Alle Integrin beta 3 (ITGB3) Antikörper anzeigen
- Integrin beta 3 (ITGB3)
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Bindungsspezifität
- AA 27-120
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Integrin beta 3 Antikörper ist konjugiert mit Alexa Fluor 350
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus
- Homologie
- Cow,Pig,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Integrin beta 3
- Isotyp
- IgG
- Top Product
- Discover our top product ITGB3 Primärantikörper
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- Applikationshinweise
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Integrin beta 3 (ITGB3)
- Andere Bezeichnung
- Integrin beta 3 (ITGB3 Produkte)
- Synonyme
- BDPLT16 antikoerper, BDPLT2 antikoerper, CD61 antikoerper, GP3A antikoerper, GPIIIa antikoerper, GT antikoerper, INGRB3 antikoerper, integrin antikoerper, INTB3 antikoerper, GPIIIA antikoerper, cd61 antikoerper, gp3a antikoerper, itgb3 antikoerper, itgb3.2 antikoerper, itgb3.1 antikoerper, integrin subunit beta 3 antikoerper, integrin beta 3 antikoerper, integrin subunit beta 3 L homeolog antikoerper, integrin beta 3a antikoerper, integrin beta 3b antikoerper, ITGB3 antikoerper, Itgb3 antikoerper, itgb3.L antikoerper, itgb3a antikoerper, itgb3b antikoerper
- Hintergrund
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Synonyms: GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, Integrin beta-3, Platelet membrane glycoprotein IIIa, ITGB3
Background: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
- Gen-ID
- 3690
- UniProt
- P05106
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
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