Human Papilloma Virus 33 E6 (HPV-33 E6) (AA 51-149) Antikörper (Cy7)

Produktnummer ABIN901228

Produktdetails

Target: Human Papilloma Virus 33 E6 (HPV-33 E6)

Bindungsspezifität: AA 51-149

Reaktivität: Alphapapillomavirus, Human Papillomavirus (HPV), Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Cy7

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Spezifität: This antibody will detect E6 in HPV33, HPV58, and Alphapapillomavirus 9.

Kreuzreaktivität: Virus

Kreuzreaktivität (Details): HPV33, HPV58, Alphapapillomavirus 9.

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HPV33 E6 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Human Papilloma Virus 33 E6 (HPV-33 E6)

Andere Bezeichnung: HPV33 E6

Substanzklasse: Viral Protein

Hintergrund:

Synonyms: E6 protein [Human papillomavirus type 33], Human Papilloma Virus, Human papillomavirus type 33, Human papillomavirus type 33, Protein 33, HPV33-E6 protein, HPV33 E6 protein, VE6_HPV33.

Background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. The E6 protein is a transcriptional transactivator. Binds double-stranded DNA. This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).