Crk Antikörper (AA 211-304) (Alexa Fluor 350)

Produktnummer ABIN892287

Produktdetails anti-Crk Antikörper (Alexa Fluor 350)

Target: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Bindungsspezifität: AA 211-304

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Crk Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Crk p38 /CrkII

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Crk

Target: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Andere Bezeichnung: Crk p38 (CRK Produkte)

Synonyme: CG1587 antikoerper, CRK antikoerper, D-CRK antikoerper, D-Crk antikoerper, DCrk antikoerper, Dcrk antikoerper, Dmel\\CG1587 antikoerper, crk antikoerper, dCRK antikoerper, dCrk antikoerper, fb34h10 antikoerper, fc05a01 antikoerper, fi19g05 antikoerper, wu:fb34h10 antikoerper, wu:fc05a01 antikoerper, wu:fc54a04 antikoerper, wu:fi19g05 antikoerper, zgc:100936 antikoerper, CRKII antikoerper, p38 antikoerper, Crko antikoerper, crk2 antikoerper, crkII antikoerper, v-crk antikoerper, P38C-CRK antikoerper, Crk-I antikoerper, Crk-II antikoerper, Crk-III antikoerper, Crk3 antikoerper, CrkIII antikoerper, c-Crk antikoerper, Crk oncogene antikoerper, v-crk avian sarcoma virus CT10 oncogene homolog antikoerper, CRK proto-oncogene, adaptor protein antikoerper, v-crk avian sarcoma virus CT10 oncogene homolog L homeolog antikoerper, v-crk sarcoma virus CT10 oncogene homolog antikoerper, Crk antikoerper, crk antikoerper, CRK antikoerper, crk.L antikoerper

Hintergrund:

Synonyms: CRK, CRK isoform 2, CrkII, CRK isoform II, CRKII, p38, Proto oncogene C crk, v crk avian sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog avian, Adapter molecule crk, Avian sarcoma virus CT10 v crk oncogene homolog.

Background: Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.

Gen-ID: 1398

Pathways: Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor