RING1 Antikörper (AA 35-39)

Produktnummer ABIN871729

Produktdetails anti-RING1 Antikörper

Target: RING1 (Ring Finger Protein 1 (RING1))

Bindungsspezifität: AA 35-39

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RING1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects endogenous level of total Ring1A protein.

Aufreinigung: Affinity purified

Immunogen: Peptide sequence around AA 35-39 ( I-A-V-S-P) derived from Human Ring1A. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu RING1

Target: RING1 (Ring Finger Protein 1 (RING1))

Andere Bezeichnung: Ring1A (RING1 Produkte)

Synonyme: RING1A antikoerper, RNF1 antikoerper, Ring1A antikoerper, bap-1 antikoerper, bap1 antikoerper, ding antikoerper, hipi3 antikoerper, ring1a antikoerper, ring1b antikoerper, ring2 antikoerper, rnf1 antikoerper, rnf2-a antikoerper, ring1 antikoerper, ring1b-B antikoerper, rnf2-b antikoerper, ring finger protein 1 antikoerper, ring finger protein 1 S homeolog antikoerper, ring finger protein 1 L homeolog antikoerper, RING1 antikoerper, Ring1 antikoerper, ring1.S antikoerper, ring1.L antikoerper

Hintergrund: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Molekulargewicht: 58 kDa

Gen-ID: 6015

NCBI Accession: NP_002922

UniProt: Q06587