MGC83599 antikoerper, D15S1518E antikoerper, HsT16821 antikoerper, LIN-10 antikoerper, MGC:14091 antikoerper, MINT2 antikoerper, X11-BETA antikoerper, X11L antikoerper, X11-like antikoerper, XllL antikoerper, mXllL antikoerper, Mint2 antikoerper, amyloid beta precursor protein binding family A member 2 antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 2 L homeolog antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 2 antikoerper, APBA2 antikoerper, apba2.L antikoerper, Apba2 antikoerper
Hintergrund
APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.Synonyms: Adapter protein X11beta, Amyloid beta A4 precursor protein-binding family A member 2, MINT2, Mint-2, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, X11L