HDAC7 Antikörper (pSer358) (Cy5.5)

Produktnummer ABIN743008

Produktdetails anti-HDAC7 Antikörper (Cy5.5)

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Bindungsspezifität: pSer358

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC7 Antikörper ist konjugiert mit Cy5.5

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus, Ratte

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human HDAC7 around the phosphorylation site of Ser358

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu HDAC7

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Andere Bezeichnung: HDAC7 (HDAC7 Produkte)

Synonyme: HD7A antikoerper, HDAC7A antikoerper, 5830434K02Rik antikoerper, HD7 antikoerper, HD7a antikoerper, Hdac7a antikoerper, mFLJ00062 antikoerper, hdac7a antikoerper, K2K18.5 antikoerper, K2K18_5 antikoerper, histone deacetylase7 antikoerper, histone deacetylase 7 antikoerper, histone deacetylase7 antikoerper, HDAC7 antikoerper, Hdac7 antikoerper, hdac7 antikoerper, HDA7 antikoerper

Hintergrund:

Synonyms: HDAC7 phospho S358, HDAC7 phospho Ser358, p-HDAC7 Ser358, HD 7a, HD7a, HDAC 7, HDAC 7A, HDAC7, HDAC7A, Histone deacetylase 7, Histone deacetylase 7A, DKFZP586J0917, OTTHUMP00000202813, OTTHUMP00000202814, FLJ99588, HDAC7_HUMAN.

Background: HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development