eIF4EBP1 Antikörper

Produktnummer ABIN742050

Der Kaninchen Polyklonal anti-eIF4EBP1 Antikörper (ABIN742050) detektiert spezifisch eIF4EBP1 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh) und Hund.

Kurzübersicht für eIF4EBP1 Antikörper (ABIN742050)

Target: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser eIF4EBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-eIF4EBP1 Antikörper

Spezifität: 60-70 % sequence similarity to 4EBP2

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human 4E-BP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu eIF4EBP1

Target: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Andere Bezeichnung: eIF4EBP1/4EBP1

Hintergrund:

Synonyms: e4EBP1, Eukaryotic translation initiation factor 4E binding protein 1, Eukaryotic translation initiation factor 4E-binding protein 1, 4E BP1, 4EBP1, BP 1, BP1, e4E binding protein 1, e4E-binding protein 1, Eukaryotic translation initiation factor 4E binding protein 1, MGC4316, PHAS I, PHASI, PHAS-I, PHAS, 4E-BP1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, Phosphorylated heat and acid stable protein regulated by insulin 1, 4EBP1_HUMAN.

Background: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].

Molekulargewicht: 12kDa

Gen-ID: 1978

Pathways: MAPK Signalweg, PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Regulation of Cell Size, BCR Signaling