Rekombinanter Insulin Antikörper

Produktnummer ABIN7543284

Der Kaninchen Chimeric anti-Insulin Antikörper wird verwendet zum Nachweis von Insulin in Proben von Human, Rind (Kuh) und Nagetiere. Er wurde validiert für ELISA, FACS und RIA.

Kurzübersicht für Rekombinanter Insulin Antikörper (ABIN7543284)

Target: Insulin (INS)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Rind (Kuh), Nagetiere

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser Insulin Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Radioimmunoassay (RIA)

Klon: Ab 123

Produktdetails anti-Insulin Antikörper

Verwendungszweck: Anti-Insulin [Ab 123 (mAb3, CC9C10)], Rabbit IgG, kappa

Spezifität:

This antibody binds an epitope on the B chain of calf, human and rodent insulin. Insulin is a peptide hormone produced by the beta cells of the pancreatic islets. It reduces blood glucose concentration by promoting its absorption from the blood into liver, fat and skeletal muscle cells. Decreased or absent insulin activity results in diabetes mellitus, a condition of high blood sugar level (hyperglycemia).

Application Notes original Clone: This antibody can be used to detect insulin in a sample using ELISA and radioimmunoassay (PMID: 2109009, 6193965). This antibody was used in the flow cytometric analysis of insulin occupied B cell receptors in VH125SD B6 mice (PMID: 26109644).

Kreuzreaktivität: Human, Nagetiere

Produktmerkmale: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing female BALB/c mice with calf insulin in Freund's complete adjuvant.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

OriginalSpeciesName: Mouse

OriginalFormat: IgG1

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu Insulin

Target: Insulin (INS)

Andere Bezeichnung: Insulin

Hintergrund: INS, proinsulin

UniProt: P01317

Pathways: NF-kappaB Signalweg, RTK Signalweg, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagie, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation