MIB2 Antikörper (AA 925-975)

Produktnummer ABIN7452954

Produktdetails anti-MIB2 Antikörper

Target: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Bindungsspezifität: AA 925-975

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MIB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit anti-MIB2/Skeletrophin Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 925 and 975

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: Not recommended

WB: 1:1,000 - 1:5,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu MIB2

Target: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Andere Bezeichnung: MIB2/Skeletrophin (MIB2 Produkte)

Synonyme: ZZANK1 antikoerper, ZZZ5 antikoerper, 2210008I11Rik antikoerper, Zzank1 antikoerper, skd antikoerper, mib2 antikoerper, mindbomb E3 ubiquitin protein ligase 2 antikoerper, mindbomb E3 ubiquitin protein ligase 2 S homeolog antikoerper, MIB2 antikoerper, Mib2 antikoerper, mib2 antikoerper, mib2.S antikoerper

Hintergrund: Background: MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.

Gen-ID: 142678

NCBI Accession: NP_543151

UniProt: Q96AX9

Pathways: Notch Signalweg