CSTF2T Antikörper (AA 225-275)

Produktnummer ABIN7452301

Produktdetails anti-CSTF2T Antikörper

Target: CSTF2T (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant (CSTF2T))

Bindungsspezifität: AA 225-275

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSTF2T Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-CSTF2T/TauCSTF64 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 225 and 275

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-CSTF2T/TauCSTF64 antibody A301-487A.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu CSTF2T

Target: CSTF2T (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant (CSTF2T))

Andere Bezeichnung: CSTF2T/TauCSTF64 (CSTF2T Produkte)

Synonyme: 64kDa antikoerper, C77975 antikoerper, tCstF-64 antikoerper, tauCstF-64 antikoerper, CstF-64T antikoerper, cleavage stimulation factor, 3' pre-RNA subunit 2, tau antikoerper, cleavage stimulation factor subunit 2 tau variant antikoerper, cleavage stimulation factor subunit 2, tau variant antikoerper, Cstf2t antikoerper, CSTF2T antikoerper

Hintergrund: Background: CSTF2T, also known as tauCSTF-64, is a paralog of CstF-64, a component of the cleavage stimulation factor (CstF) that processes 3'-end formation and polyadenylation of mRNAs. The human CSTF2T/TauCSTF64 gene is located at 10q22-23, a site associated with neurological problems and male infertility. CSTF2T is expressed in all tissues and throughout meiosis in male germ cells. CstF-64 is also expressed ubiquitously, however because it is located on the X chromosome, its expression is temporarily silenced in germ cells by meiotic sex chromosome inactivation. During this inactivation, it is hypothesized that CSTF2T/TauCSTF64 can compensate for the loss of CstfF-64 expression. Recently, targeted disruption of CSTF2T/TauCSTF64 in mice has been shown to cause aberrant spermatogenesis and infertility providing more evidence for its importance in spermatogenesis.

Gen-ID: 23283

NCBI Accession: NP_056050

UniProt: Q9H0L4