SMARCAL1 Antikörper (AA 904-954)

Produktnummer ABIN7452047

Produktdetails anti-SMARCAL1 Antikörper

Target: SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1))

Bindungsspezifität: AA 904-954

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMARCAL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-SMARCAL1 Antibody, Affinity Purified

Homologie: Bovine

Aufreinigung: Affinity Purified

Immunogen: between AA 904 and 954

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu SMARCAL1

Target: SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1))

Andere Bezeichnung: SMARCAL1 (SMARCAL1 Produkte)

Synonyme: SMARCAL1 antikoerper, im:7145331 antikoerper, si:ch211-239d11.1 antikoerper, harp antikoerper, hharp antikoerper, 6030401P21Rik antikoerper, AI851716 antikoerper, Mharp antikoerper, HARP antikoerper, HHARP antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 antikoerper, SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 antikoerper, Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 L homeolog antikoerper, SMARCAL1 antikoerper, smarcal1 antikoerper, Smarcal1 antikoerper, smarcal1.L antikoerper

Hintergrund: Background: The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. SMARCAL1 is a member of the SNF2 family. SMARCAL1 is also known as human hep-related protein (HARP) due to its sequence identity with the E. coli RNA polymerase-binding protein HepA. It has been determined that mutations in SMARCAL1 are the cause of Schimke immuno-osseous dysplasia (SIOD), an autosomal-recessive disorder characterized by spondyloepiphyseal dysplasia, renal dysfunction, facial dysmorphism, and T-cell immunodeficiency. The pleiotropic characteristics of SIOD indicate an important role for SMARCAL1 in the regulation of multiple genes that influence the proliferation of chondrocytes, lymphocytes, and spermatozytes, as well as the development of cardiomyocytes and vascular homeostasis.

Gen-ID: 50485

NCBI Accession: NP_054859

UniProt: Q9NZC9

Pathways: Embryonic Body Morphogenesis