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BEBOV GP Antikörper

BEBOV GP Reaktivität: Ebola Virus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7383889
  • Target Alle BEBOV GP Produkte
    BEBOV GP (Bundibugyo Ebola Virus Envelope Glycoprotein (BEBOV GP))
    Reaktivität
    Ebola Virus
    Wirt
    • 1
    Kaninchen
    Klonalität
    • 1
    Polyklonal
    Konjugat
    • 1
    Dieser BEBOV GP Antikörper ist unkonjugiert
    Applikation
    Western Blotting (WB), ELISA
    Spezifität
    Anti-Ebola virus EBOV(subtype Bundibugyo, strain Uganda 2007) Glycoprotein/GP Polyclonal Antibody
    Aufreinigung
    Antigen Affinity
    Immunogen
    Recombinant EBOV (subtype Bundibugyo, strain Uganda 2007) GP1 / Glycoprotein Protein (His Tag), ABIN7198902
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000 ELISA 1:5000-1:10000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    0.2 μm filtered solution in PBS
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    BEBOV GP (Bundibugyo Ebola Virus Envelope Glycoprotein (BEBOV GP))
    Andere Bezeichnung
    BEBOV Glycoprotein/GP (BEBOV GP Produkte)
    Hintergrund
    Glycoprotein,GP,The fourth gene of the EBOV genome encodes a 16- kDa envelope-attached glycoprotein (GP) and a 11 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD), the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, β-integrins, folate receptor-α, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry, the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm.
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