ZCCHC3 Antikörper (AA 215-335)

Produktnummer ABIN7271543

Produktdetails anti-ZCCHC3 Antikörper

Target: ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))

Bindungsspezifität: AA 215-335

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZCCHC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Verwendungszweck: ZCCHC3 Rabbit pAb

Sequenz: SFRSAEKLAL FLRVYEEKRE QEDCWENFVV LGRSKSSLKT LFILFRNETV DVEDIVTWLK RHCDVLAVPV KVTDRFGIWT GEYKCEIELR QGEGGVRHLP GAFFLGAERG YSWYKGQPKT C

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 215-335 of human ZCCHC3 (NP_149080.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ZCCHC3

Target: ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))

Andere Bezeichnung: ZCCHC3 (ZCCHC3 Produkte)

Synonyme: C20orf99 antikoerper, 2810406K24Rik antikoerper, zinc finger CCHC-type containing 3 antikoerper, zinc finger, CCHC domain containing 3 antikoerper, ZCCHC3 antikoerper, Zcchc3 antikoerper

Hintergrund: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses. Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS. Acts as a co-sensor for recognition of double-stranded DNA (dsDNA by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus. Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation. Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA, enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5.,ZCCHC3,C20orf99,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,ZCCHC3

Molekulargewicht: 43kDa

Gen-ID: 85364

UniProt: Q9NUD5