OTUD7B Antikörper (AA 530-700)

Produktnummer ABIN7269125

Produktdetails anti-OTUD7B Antikörper

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Bindungsspezifität: AA 530-700

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTUD7B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: OTUD7B Rabbit pAb

Sequenz: SKPGGVGTGL GGSSGTETLE KKKKNSLKSW KGGKEEAAGD GPVSEKPPAE SVGNGGSKYS QEVMQSLSIL RTAMQGEGKF IFVGTLKMGH RHQYQEEMIQ RYLSDAEERF LAEQKQKEAE RKIMNGGIGG GPPPAKKPEP DAREEQPTGP PAESRAMAFS TGYPGDFTIP R

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 530-700 of human OTUD7B (NP_064590.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu OTUD7B

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Andere Bezeichnung: OTUD7B (OTUD7B Produkte)

Synonyme: OTUD7B antikoerper, ZA20D1 antikoerper, za20d1 antikoerper, zgc:152772 antikoerper, cezanne antikoerper, CEZANNE antikoerper, 2900060B22Rik antikoerper, 4930463P07Rik antikoerper, AI462125 antikoerper, Trabid2 antikoerper, Za20d1 antikoerper, RGD1308111 antikoerper, OTU deubiquitinase 7B antikoerper, OTU domain containing 7B antikoerper, OTUD7B antikoerper, otud7b antikoerper, Otud7b antikoerper

Hintergrund: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro, however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin.,OTUD7B,CEZANNE,ZA20D1,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,OTUD7B

Molekulargewicht: 88kDa/92kDa

Gen-ID: 56957

UniProt: Q6GQQ9