METTL16 Antikörper (AA 263-562)

Produktnummer ABIN7268501

Produktdetails anti-METTL16 Antikörper

Target: METTL16 (Methyltransferase Like 16 (METTL16))

Bindungsspezifität: AA 263-562

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser METTL16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Verwendungszweck: METTL16 Rabbit pAb

Sequenz: RIQGVPKVTY TEFCQGRTMR WALAWSFYDD VTVPSPPSKR RKLEKPRKPI TFVVLASVMK ELSLKASPLR SETAEGIVVV TTWIEKILTD LKVQHKRVPC GKEEVSLFLT AIENSWIHLR RKKRERVRQL REVPRAPEDV IQALEEKKPT PKESGNSQEL ARGPQERTPC GPALREGEAA AVEGPCPSQE SLSQEENPEP TEDERSEEKG GVEVLESCQG SSNGAQDQEA SEQFGSPVAE RGKRLPGVAG QYLFKCLINV KKEVDDALVE MHWVEGQNRD LMNQLCTYIR NQIFRLVAVN

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 263-562 of human METTL16 (NP_076991.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu METTL16

Target: METTL16 (Methyltransferase Like 16 (METTL16))

Andere Bezeichnung: METTL16 (METTL16 Produkte)

Synonyme: fi09d09 antikoerper, im:7148386 antikoerper, mett10d antikoerper, wu:fi09d09 antikoerper, zgc:100981 antikoerper, zgc:158576 antikoerper, METT10D antikoerper, 2610100D03Rik antikoerper, 2810013M15Rik antikoerper, A830095F14Rik antikoerper, AI846133 antikoerper, Mett10d antikoerper, methyltransferase like 16 antikoerper, methyltransferase like 16 L homeolog antikoerper, mettl16 antikoerper, mettl16.L antikoerper, METTL16 antikoerper, Mettl16 antikoerper

Hintergrund: RNA N6-methyltransferase that methylates adenosine residues at the N(6 position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs. In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA: specifically N6-methylates adenine in position 43 of U6 snRNAs. Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA or 7SL RNA. Specifically binds the 3'-end of the MALAT1 long non-coding RNA.,METTL16,METT10D,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,METTL16

Molekulargewicht: 25kDa/63kDa

Gen-ID: 79066

UniProt: Q86W50