Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3) Antikörper

Produktnummer ABIN7267792

Produktdetails

Target: Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Verwendungszweck: Hivep3 Rabbit pAb

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of Mouse Hivep3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Antigendetails

Target: Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3)

Andere Bezeichnung: Hivep3 (HIVEP3 Produkte)

Synonyme: 2900056N03Rik antikoerper, A130075N07 antikoerper, AI848000 antikoerper, E030045D18Rik antikoerper, KBP-1 antikoerper, KBP1 antikoerper, Krc antikoerper, Rc antikoerper, Schnurri-3 antikoerper, Shn3 antikoerper, Zas3 antikoerper, KRC antikoerper, SHN3 antikoerper, ZAS3 antikoerper, ZNF40C antikoerper, human immunodeficiency virus type I enhancer binding protein 3 antikoerper, human immunodeficiency virus type I enhancer binding protein 3 L homeolog antikoerper, transcription factor HIVEP3 antikoerper, HIVEP3 antikoerper, hivep3.L antikoerper, LOC100409919 antikoerper, hivep3 antikoerper, Hivep3 antikoerper

Hintergrund: Plays a role of transcription factor, binds to recognition signal sequences (Rss heptamer for somatic recombination of immunoglobulin and T-cell receptor gene segments, Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation, Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus, through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.,Kr, Rc, Sh, Krc, KBP1, Shn3, Zas3, KBP-1, Schnu, AI848000, A130075N07, Schnurri-3, 2900056N03Rik, E030045D18Rik,Hivep3

Molekulargewicht: 253kDa

Gen-ID: 16656

UniProt: A2A884