CIC Antikörper (AA 1379-1608)

Produktnummer ABIN7266060

Produktdetails anti-CIC Antikörper

Target: CIC (Capicua Homolog (CIC))

Bindungsspezifität: AA 1379-1608

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CIC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: CIC Rabbit pAb

Sequenz: LATSPRAILG SYRKKRKNST DLDSAPEDPT SPKRKMRRRS SCSSEPNTPK SAKCEGDIFT FDRTGTEAED VLGELEYDKV PYSSLRRTLD QRRALVMQLF QDHGFFPSAQ ATAAFQARYA DIFPSKVCLQ LKIREVRQKI MQAATPTEQP PGAEAPLPVP PPTGTAAAPA PTPSPAGGPD PTSPSSDSGT AQAAPPLPPP PESGPGQPGW EGAPQPSPPP PGPSTAATGR

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1379-1608 of human CIC (NP_055940.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CIC

Target: CIC (Capicua Homolog (CIC))

Andere Bezeichnung: CIC (CIC Produkte)

Synonyme: wu:fb93c01 antikoerper, CIC antikoerper, 1200010B10Rik antikoerper, mKIAA0306 antikoerper, capicua transcriptional repressor b antikoerper, capicua transcriptional repressor antikoerper, cicb antikoerper, CIC antikoerper, Cic antikoerper

Hintergrund: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.,CIC,Epigenetics & Nuclear Signaling,Neuroscience,Neurodegenerative Diseases,CIC

Molekulargewicht: 163kDa

Gen-ID: 23152

UniProt: Q96RK0