CABLES2 Antikörper

Produktnummer ABIN7190032

Produktdetails anti-CABLES2 Antikörper

Target: CABLES2 (Cdk5 and Abl Enzyme Substrate 2 (CABLES2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CABLES2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of Human CABLES2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA:1:1000-1:2000, IHC:1:25-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CABLES2

Target: CABLES2 (Cdk5 and Abl Enzyme Substrate 2 (CABLES2))

Andere Bezeichnung: CABLES2 (CABLES2 Produkte)

Synonyme: cables2 antikoerper, CABLES2 antikoerper, C20orf150 antikoerper, dJ908M14.2 antikoerper, ik3-2 antikoerper, Cdk5 and Abl enzyme substrate 2 antikoerper, CDK5 and Abl enzyme substrate 2 antikoerper, CABLES2 antikoerper, cables2 antikoerper, Cables2 antikoerper

Hintergrund:

Background: Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78 % sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.

Aliases: CABLES2 antibody, C20orf150 antibody, CDK5 and ABL1 enzyme substrate 2 antibody, Interactor with CDK3 2 antibody, Ik3-2 antibody

UniProt: Q9BTV7