SCN5A Antikörper

Produktnummer ABIN7182719

Produktdetails anti-SCN5A Antikörper

Target: SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SCN5A Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human sodium channel.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SCN5A

Target: SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))

Andere Bezeichnung: SCN5A (SCN5A Produkte)

Synonyme: Nav1.5 antikoerper, Nav1.5c antikoerper, SkM1 antikoerper, SkM2 antikoerper, mH1 antikoerper, CDCD2 antikoerper, CMD1E antikoerper, CMPD2 antikoerper, HB1 antikoerper, HB2 antikoerper, HBBD antikoerper, HH1 antikoerper, ICCD antikoerper, IVF antikoerper, LQT3 antikoerper, PFHB1 antikoerper, SSS1 antikoerper, VF1 antikoerper, SCAL antikoerper, sodium voltage-gated channel alpha subunit 5 antikoerper, sodium channel, voltage-gated, type V, alpha antikoerper, SCN5A antikoerper, Scn5a antikoerper

Hintergrund:

Background: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.

Sebastian K.G. Maier, Circulation, Mar 2004, 109: 1421 - 1427.
T.R. Cummins, Neurology, Jan 2003, 60: 224 - 229.
Christopher A. Ahern, Circ. Res., May 2005, 96: 991 - 998.
Jyoti Dhar Malhotra, Circulation, Mar 2001, 103: 1303 - 1310.

Aliases: Cardiac tetrodotoxin insensitive voltage dependent sodium channel alpha subunit antibody, CDCD2 antibody, CMD1E antibody, CMPD2 antibody, HB1 antibody, HB2 antibody, HBBD antibody, HH1 antibody, ICCD antibody, IVF antibody, LQT3 antibody, PFHB1 antibody, Scn5a (gene name) antibody, Scn5a antibody, SCN5A_HUMAN antibody, Sodium channel protein cardiac muscle alpha subunit antibody, Sodium channel protein cardiac muscle subunit alpha antibody, Sodium channel protein type 5 subunit alpha antibody, Sodium channel protein type V alpha subunit antibody, Sodium channel protein type V subunit alpha antibody, SSS1 antibody, VF1 antibody, Voltage gated sodium channel alpha subunit Nav1.5 antibody, Voltage-gated sodium channel subunit alpha Nav1.5 antibody

UniProt: Q14524