Vpx Protein (VPX) (AA 1-112) Antikörper (HRP)

Produktnummer ABIN7179352

Produktdetails

Target: Vpx Protein (VPX)

Bindungsspezifität: AA 1-112

Reaktivität: Simian Immunodeficiency Virus (SIV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: HRP

Applikation: ELISA

Kreuzreaktivität: Simian Immunodeficiency Virus (SIV)

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Antigendetails

Target: Vpx Protein (VPX)

Andere Bezeichnung: vpx (VPX Produkte)

Synonyme: vpx protein antikoerper, vpx antikoerper

Substanzklasse: Viral Protein

Hintergrund:

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

Aliases: vpx antibody, Protein Vpx antibody, Viral protein X antibody, X ORF protein antibody

UniProt: P11266