VPS16 Antikörper (AA 7-89)

Produktnummer ABIN7175666

Produktdetails anti-VPS16 Antikörper

Target: VPS16 (Vacuolar Protein Sorting-Associated Protein 16 Homolog (VPS16))

Bindungsspezifität: AA 7-89

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human VPS16 protein (7-89AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VPS16

Target: VPS16 (Vacuolar Protein Sorting-Associated Protein 16 Homolog (VPS16))

Andere Bezeichnung: VPS16 (VPS16 Produkte)

Synonyme: 1810074M16Rik antikoerper, hVPS16 antikoerper, VPS16A antikoerper, vacuolar protein sorting protein 16 antikoerper, Vacuolar protein sorting-associated protein 16 homolog antikoerper, VSP16 CORVET/HOPS core subunit antikoerper, VPS16, CORVET/HOPS core subunit antikoerper, vacuolar protein sorting 16 homolog (S. cerevisiae) antikoerper, VPS16 CORVET/HOPS core subunit antikoerper, Tc00.1047053506367.60 antikoerper, Tc00.1047053508355.200 antikoerper, vps-16 antikoerper, Vps16 antikoerper, VPS16 antikoerper

Hintergrund:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes, the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).

Aliases: Vacuolar protein sorting-associated protein 16 homolog (hVPS16), VPS16

UniProt: Q6GMQ7