PTPN22 Antikörper (AA 1-179)
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- Target Alle PTPN22 Antikörper anzeigen
- PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
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Bindungsspezifität
- AA 1-179
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PTPN22 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunofluorescence (IF)
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Tyrosine-protein phosphatase non-receptor type 22 protein (1-179AA)
- Isotyp
- IgG
- Top Product
- Discover our top product PTPN22 Primärantikörper
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- Applikationshinweise
- Recommended dilution: IF:1:200-1:500,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
- Andere Bezeichnung
- PTPN22 (PTPN22 Produkte)
- Synonyme
- 70zpep antikoerper, PEP antikoerper, Ptpn8 antikoerper, LYP antikoerper, LYP1 antikoerper, LYP2 antikoerper, PTPN8 antikoerper, protein tyrosine phosphatase, non-receptor type 22 (lymphoid) antikoerper, protein tyrosine phosphatase, non-receptor type 22 antikoerper, Ptpn22 antikoerper, PTPN22 antikoerper
- Hintergrund
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Background: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating \'Tyr-394\' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating \'Tyr-493\' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).
Aliases: Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody, Lymphoid phosphatase antibody, Lymphoid specific protein tyrosine phosphatase antibody, lymphoid-specific, inducible human protein tyrosine phosphatase antibody, Lyp 1 antibody, Lyp 2 antibody, LyP antibody, Lyp1 antibody, Lyp2 antibody, LyPTP antibody, OTTHUMP00000013720 antibody, OTTHUMP00000013721 antibody, OTTHUMP00000233450 antibody, OTTHUMP00000233451 antibody, PEP antibody, PEST-domain phosphatase antibody, Protein tyrosine phosphatase non receptor type 22 (lymphoid) antibody, Protein tyrosine phosphatase non receptor type 22 antibody, Protein tyrosine phosphatase non receptor type 8 antibody, Protein tyrosine phosphatase non receptor type 8, formerly antibody, PTN22_HUMAN antibody, PTPN 22 antibody, PTPN 8 antibody, Ptpn22 antibody, PTPN8 antibody, PTPN8, formerly antibody, Tyrosine-protein phosphatase non-receptor type 22 antibody
- UniProt
- Q9Y2R2
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