TRPM8 Antikörper (AA 1-192)
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- Target Alle TRPM8 Antikörper anzeigen
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
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Bindungsspezifität
- AA 1-192
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TRPM8 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Transient receptor potential cation channel subfamily M member 8 protein (1-192AA)
- Isotyp
- IgG
- Top Product
- Discover our top product TRPM8 Primärantikörper
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- Applikationshinweise
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- Andere Bezeichnung
- TRPM8 (TRPM8 Produkte)
- Synonyme
- TRPM8 antikoerper, trpp8 antikoerper, ltrpc6 antikoerper, trpm8b antikoerper, LTRPC6 antikoerper, TRPP8 antikoerper, CMR1 antikoerper, LTrpC-6 antikoerper, Trp-p8 antikoerper, transient receptor potential cation channel subfamily M member 8 antikoerper, transient receptor potential cation channel subfamily M member 8b L homeolog antikoerper, transient receptor potential cation channel, subfamily M, member 8 antikoerper, TRPM8 antikoerper, trpm8b.L antikoerper, Trpm8 antikoerper
- Hintergrund
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Background: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
Aliases: Long transient receptor potential channel 6 antibody, LTrpC-6 antibody, LTrpC6 antibody, MGC2849 antibody, Short form of the TRPM8 cationic channel antibody, Transient receptor potential cation channel subfamily M member 8 antibody, Transient receptor potential p8 antibody, transient receptor potential-p8 antibody, Trp p8 antibody, Trp-p8 antibody, Trpm8 antibody, TRPM8_HUMAN antibody, TRPP8 antibody
- UniProt
- Q7Z2W7
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