PTPRB Antikörper (AA 1758-1997)

Produktnummer ABIN7167501

Produktdetails anti-PTPRB Antikörper

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Bindungsspezifität: AA 1758-1997

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPRB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Receptor-type tyrosine-protein phosphatase beta protein (1758-1997AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PTPRB

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Andere Bezeichnung: PTPRB (PTPRB Produkte)

Synonyme: PTPRB antikoerper, HPTP-BETA antikoerper, HPTPB antikoerper, PTPB antikoerper, R-PTP-BETA antikoerper, VEPTP antikoerper, 3230402H02Rik antikoerper, C130094E24 antikoerper, Ptpz antikoerper, Rptpb antikoerper, VE-PTP antikoerper, Veptp antikoerper, protein tyrosine phosphatase, receptor type B antikoerper, receptor-type tyrosine-protein phosphatase beta antikoerper, protein tyrosine phosphatase, receptor type, B antikoerper, PTPRB antikoerper, LOC100380677 antikoerper, Ptprb antikoerper

Hintergrund:

Background: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Aliases: HPTP BETA antibody, HPTPB antibody, Phosphacan receptor type B antibody, Protein tyrosine phosphatase receptor type B antibody, Protein-tyrosine phosphatase beta antibody, PTPB antibody, Ptprb antibody, PTPRB_HUMAN antibody, R PTP BETA antibody, R-PTP-beta antibody, Receptor-type tyrosine-protein phosphatase beta antibody, RPTPB antibody, Vascular endothelial protein tyrosine phosphatase antibody, VE-PTP antibody

UniProt: P23467