PAD4 Antikörper (AA 1-250)

Produktnummer ABIN7361722

Produktdetails anti-PAD4 Antikörper

Target: PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))

Bindungsspezifität: AA 1-250

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAD4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Protein-arginine deiminase type-4 protein (1-250AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PAD4

Target: PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))

Andere Bezeichnung: PADI4 (PADI4 Produkte)

Synonyme: PAD antikoerper, PAD4 antikoerper, PADI5 antikoerper, PDI4 antikoerper, PDI5 antikoerper, Pad4 antikoerper, Pdi4 antikoerper, peptidyl arginine deiminase 4 antikoerper, peptidyl arginine deiminase, type IV antikoerper, PADI4 antikoerper, Padi4 antikoerper

Hintergrund:

Background: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at \\\'Arg-54\\\' (to form H1R54ci), histone H3 at \\\'Arg-2\\\', \\\'Arg-8\\\', \\\'Arg-17\\\' and/or \\\'Arg-26\\\' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at \\\'Arg-3\\\' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of \\\'Arg-54\\\' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at \\\'Arg-2142\\\', which favors its interaction with NCOA2/GRIP1.

Aliases: EC 3.5.3.15 antibody, HL 60 PAD antibody, HL-60 PAD antibody, PAD 4 antibody, PAD antibody, PADI 4 antibody, PADI 5 antibody, PADI H protein antibody, Padi4 antibody, PADI4_HUMAN antibody, PADI5 antibody, PDI 4 antibody, PDI 5 antibody, PDI4 antibody, PDI5 antibody, Peptidyl arginine deiminase type IV antibody, Peptidyl arginine deiminase type V antibody, Peptidylarginine deiminase IV antibody, Protein arginine deiminase antibody, Protein arginine deiminase type 4 antibody, Protein arginine deiminase type IV antibody, Protein-arginine deiminase type IV antibody, Protein-arginine deiminase type-4 antibody

UniProt: Q9UM07