POU4F1 Antikörper (AA 258-419) (FITC)

Produktnummer ABIN7164065

Produktdetails anti-POU4F1 Antikörper (FITC)

Target: POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))

Bindungsspezifität: AA 258-419

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POU4F1 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human POU domain, class 4, transcription factor 1 protein (258-419AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu POU4F1

Target: POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))

Andere Bezeichnung: POU4F1 (POU4F1 Produkte)

Synonyme: BRN3A antikoerper, Oct-T1 antikoerper, RDC-1 antikoerper, brn-3A antikoerper, POU4F1 antikoerper, Brn-3a antikoerper, Brn-3 antikoerper, Brn-3.0 antikoerper, Brn3 antikoerper, Brn3.0 antikoerper, Brn3a antikoerper, E130119J07Rik antikoerper, brn3.0 antikoerper, brn3a antikoerper, brn3a-A antikoerper, oct-t1 antikoerper, rdc-1 antikoerper, POU class 4 homeobox 1 antikoerper, POU domain, class 4, transcription factor 1 antikoerper, POU class 4 homeobox 1 L homeolog antikoerper, POU4F1 antikoerper, Pou4f1 antikoerper, pou4f1 antikoerper, Tsp_01181 antikoerper, pou4f1.L antikoerper

Hintergrund:

Background: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5\'-ATGCAAAT-3\' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.

Aliases: Brain specific homeobox/POU domain protein 3A antibody, Brain-3A antibody, Brain-specific homeobox/POU domain protein 3A antibody, Brn 3.0 antibody, BRN 3A antibody, Brn-3A antibody, Brn3 antibody, BRN3A antibody, class 4 antibody, FLJ13449 antibody, Homeobox/POU domain protein RDC 1 antibody, Homeobox/POU domain protein RDC-1 antibody, Homeobox/POU domain protein RDC1 antibody, Oct T1 antibody, Oct-T1 antibody, OctT1 antibody, PO4F1_HUMAN antibody, POU class 4 homeobox 1 antibody, POU domain antibody, POU Domain Class 4 Transcription Factor 1 antibody, Pou4f1 antibody, RDC 1 antibody, RDC1 antibody, transcription factor 1 antibody

UniProt: Q01851

Pathways: Feeding Behaviour