PLEKHO1 Antikörper (AA 143-404) (Biotin)

Produktnummer ABIN7163659

Produktdetails anti-PLEKHO1 Antikörper (Biotin)

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Bindungsspezifität: AA 143-404

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLEKHO1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PLEKHO1

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Andere Bezeichnung: PLEKHO1 (PLEKHO1 Produkte)

Synonyme: CKIP-1 antikoerper, OC120 antikoerper, 2810052M02Rik antikoerper, Ckip1 antikoerper, JZA-20 antikoerper, Jza2 antikoerper, RGD1311487 antikoerper, ckip-1 antikoerper, plekho1 antikoerper, si:dkey-200h23.2 antikoerper, pleckstrin homology domain containing O1 antikoerper, pleckstrin homology domain containing, family O member 1 antikoerper, pleckstrin homology domain containing, family O member 1a antikoerper, PLEKHO1 antikoerper, Plekho1 antikoerper, plekho1a antikoerper

Hintergrund:

Background: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Aliases: C-Jun-binding protein antibody, Casein kinase 2-interacting protein 1 antibody, CK2 interacting protein 1 antibody, CK2 interacting protein 1 HQ0024c protein antibody, CK2-interacting protein 1 antibody, CKIP 1 antibody, CKIP-1 antibody, CKIP1 antibody, JBP antibody, OC120 antibody, Osteoclast maturation associated gene 120 protein antibody, Osteoclast maturation-associated gene 120 protein antibody, PH domain-containing family O member 1 antibody, PKHO1_HUMAN antibody, Pleckstrin homology domain containing family O member 1 antibody, Pleckstrin homology domain-containing family O member 1 antibody, PLEKHO1 antibody

UniProt: Q53GL0