PHAX Antikörper (AA 6-243) (Biotin)

Produktnummer ABIN7163410

Produktdetails anti-PHAX Antikörper (Biotin)

Target: PHAX (phosphorylated Adaptor For RNA Export (PHAX))

Bindungsspezifität: AA 6-243

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHAX Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Phosphorylated adapter RNA export protein (6-243AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PHAX

Target: PHAX (phosphorylated Adaptor For RNA Export (PHAX))

Andere Bezeichnung: PHAX (PHAX Produkte)

Synonyme: RNUXA antikoerper, 2810055C14Rik antikoerper, 4933427L19Rik antikoerper, AU018701 antikoerper, AU018854 antikoerper, D18Ertd65e antikoerper, Rnuxa antikoerper, p55 antikoerper, phosphorylated adaptor for RNA export antikoerper, PHAX antikoerper, Phax antikoerper

Hintergrund:

Background: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

Aliases: FLJ13193 antibody, PHAX antibody, PHAX_HUMAN antibody, Phosphorylated adapter RNA export protein antibody, Phosphorylated adaptor for RNA export antibody, RNA U small nuclear RNA export adapter protein antibody, RNA U, small nuclear RNA export adapter (phosphorylation regulated) antibody, RNUXA antibody

UniProt: Q9H814

Pathways: Ribonucleoprotein Complex Subunit Organization