ATP8B1 Antikörper (AA 217-330)

Produktnummer ABIN7163374

Produktdetails anti-ATP8B1 Antikörper

Target: ATP8B1 (ATPase, Class I, Type 8B, Member 1 (ATP8B1))

Bindungsspezifität: AA 217-330

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP8B1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Phospholipid-transporting ATPase IC protein (217-330AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ATP8B1

Target: ATP8B1 (ATPase, Class I, Type 8B, Member 1 (ATP8B1))

Andere Bezeichnung: ATP8B1 (ATP8B1 Produkte)

Synonyme: bric antikoerper, fic1 antikoerper, pfic antikoerper, atpic antikoerper, pfic1 antikoerper, MGC69272 antikoerper, ATPIC antikoerper, BRIC antikoerper, FIC1 antikoerper, ICP1 antikoerper, PFIC antikoerper, PFIC1 antikoerper, AI451886 antikoerper, Ic antikoerper, ATPase phospholipid transporting 8B1 antikoerper, ATPase phospholipid transporting 8B1 S homeolog antikoerper, ATPase, class I, type 8B, member 1 antikoerper, Atp8b1 antikoerper, ATP8B1 antikoerper, atp8b1 antikoerper, atp8b1.S antikoerper

Hintergrund:

Background: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells, the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury.

Aliases: AT8B1_HUMAN antibody, ATP8B1 antibody, ATPase class I type 8B member 1 antibody, ATPase, aminophospholipid transporter, class I, type 8B, member 1 antibody, ATPIC antibody, BRIC antibody, E1-E2 ATPase antibody, Familial intrahepatic cholestasis type 1 antibody, FIC1 antibody, OTTHUMP00000163615 antibody, PFIC antibody, PFIC1 antibody, Phospholipid transporting ATPase IC antibody, Probable phospholipid-transporting ATPase IC antibody

UniProt: O43520